Ludwig-Maximilians-Universität München, Osman Lab -
Cell and Developmental Biology

 Martinsried
 Employees: less than 10

The viability and function of every eukaryotic cell crucially depends on its supply with energy. The majority of this energy is generated in mitochondria in the form of ATP by multisubunit-complexes of the respiratory chain in a process known as oxidative phosphorylation. While most of the subunits of the respiratory chain complexes are encoded in the nuclear genome and are imported into mitochondria post-translationally, a few essential subunits are encoded in the mitochondrial genome (mtDNA), which is thus absolutely essential for oxidative phosphorylation and mitochondrial and cellular function. mtDNA is present in tens to hundreds of copies in every cell, which are distributed throughout the tubular and reticulated mitochondrial network.

Given the importance of mtDNA for cellular energy supply, it is not surprising that mutations within mtDNA have been identified as the cause for a multitude of human diseases and have been tightly linked to the ageing process and altered stem cell homeostasis. Accordingly, to ensure organismal health, good copies of mtDNA have to be faithfully inherited during cell division, their integrity needs to be maintained over generations and they need to be distributed throughout the mitochondrial network to provide all mitochondrial segments with mtDNA encoded proteins. Astonishingly, it remains poorly understood how cells accomplish these fundamental tasks. It is the aim of our lab to shed light on the mechanisms that underlie these fascinating processes.

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Way of application:
  • Apply via E-Mail

Facts

Value of employees: less than 10
Expansion: national

In our company employees are working in the following fields:
Research & Education, Research Associate

In our company employees with these qualifications are welcome:
Biology & Life Sciences, Data Science & Database

Location

Ludwig-Maximilians-Universität München, Osman Lab
Cell and Developmental Biology
Großhaderner Str. 2
Biocenter of the LMU
82152 Martinsried
Germany