Research Group Roland Lang
Balancing Innate Immune Activation and Deactivation
The question driving our research is how the immune system generates resistence to infection without causing excessive inflammation. Innate immunity’s pattern recognition receptors trigger rapid and robust anti-microbial responses. The risk of collateral damage creates a need for endogenous molecular brakes. We focus on macrophages because of their dual role as sensors of infection and innate immune effector cells. Insights into the mechanisms of activation and deactivation may be harnessed for immune modulation: more robust innate immune activation for improved vaccination or attenuation of pathological acute or chronic inflammatory responses.
We welcome applications for PhD student positions from highly motivated young life scientists.
Klinische Mikrobiologie und Immunologie, AG Lang
Research & Education