The focus of our research interest is on the molecular elucidation of human disease with a special focus on growth and neuronal disorders. To uncover the basic mechanisms on the causes of these disorders, our work employs different cell culture and animal models as well as differentiated embryonic stem cells. We would like to understand how mutations correlate with disease, how genes are regulated and how they contribute to differentiation and development. By integrating genetic, molecular, biochemical and cell biological approaches, the basic understanding and function of these proteins and their roles in the relevant networks will be established.
Currently we are focussing on the following projects:
The short stature homeodomain protein SHOX
The homeodomain transcription factor SHOX2
The functional role of MEGAP in neuronal development
The serotonin 5-HT3 receptor genes
Our work is supported by Heidelberg University, DFG-German Research Foundation, BMBF – Federal Ministry of Education and Research, Deutsche Krebshilfe - German Cancer Aid, Industry, Sander Stiftung, Excellenzcluster (Cell Net Works).
Institut für Humangenetik, Abt. Molekulare Humangenetik
Im Neuenheimer Feld 366