Are you passionate about cutting-edge research at the intersection of life sciences and engineering? We are looking for highly motivated PhD students eager to push boundaries in fields such as biology, chemistry, physics, electrical or mechanical engineering, computer science, or micro- and nanotechnology.
As a PhD student in our structured and international Graduate School Life Science Engineering, you will be part of a dynamic, interdisciplinary research community, working on innovative projects that drive scientific progress.
As a PhD student in our structured and international Graduate School Life Science Engineering, you will be part of a dynamic, interdisciplinary research community, working on innovative projects that drive scientific progress.
Exciting PhD Opportunity in 'Life Science Engineering' at TU Darmstadt
Activities and responsibilities
Join the lab of Prof. Cristina Cardoso - Cell biology & epigenetics
One focus of our research is how the mammalian genome is maintained through cell divisions and in response to endogenous and exogenous stress. The genome contains all the information to build hundreds of different cells and entire organisms and must be copied in every cell division. A single mistake could lead to tumor formation. Using live-cell and super-resolution techniques of genomically engineered cell lines, we investigate the spatio-temporal dynamics and regulation of genome replication in cells at different developmental stages comparing e. g. (embryonic) stem cells and tumor cells.
Another focus of our research is to investigate how writers and readers DNA modifications control the packing of the over 2 meters of DNA into the micrometer-sized cell nucleus. Using a combination of biochemical and cell biological techniques together with proteomics, we investigate how DNA modifications affect chromatin compartmentalization and how that impacts on genome activity and stability during cellular differentiation, reprogramming or disease.
Last not least, our smallest tools, the cell permeable peptides and nanobodies. We used this method to deliver substances including nanobodies into cells to engineer and investigate cellular functions.
The position is available initially for three years.
One focus of our research is how the mammalian genome is maintained through cell divisions and in response to endogenous and exogenous stress. The genome contains all the information to build hundreds of different cells and entire organisms and must be copied in every cell division. A single mistake could lead to tumor formation. Using live-cell and super-resolution techniques of genomically engineered cell lines, we investigate the spatio-temporal dynamics and regulation of genome replication in cells at different developmental stages comparing e. g. (embryonic) stem cells and tumor cells.
Another focus of our research is to investigate how writers and readers DNA modifications control the packing of the over 2 meters of DNA into the micrometer-sized cell nucleus. Using a combination of biochemical and cell biological techniques together with proteomics, we investigate how DNA modifications affect chromatin compartmentalization and how that impacts on genome activity and stability during cellular differentiation, reprogramming or disease.
Last not least, our smallest tools, the cell permeable peptides and nanobodies. We used this method to deliver substances including nanobodies into cells to engineer and investigate cellular functions.
The position is available initially for three years.
Qualification profile
Please review the application requirements and admission process carefully BEFORE submitting your application here .
We offer
- A unique, interdisciplinary PhD program tailored to your academic and professional growth
- Personalized supervision by a dedicated Thesis Advisory Committee
- A mobility allowance for research stays abroad and the participation in (inter)national conferences
- Extracurricular seminars and trainings in transferable skills
If you are excited to join the Graduate School in Life Science Engineering, apply now via the apply button.
We look forward to receiving your application and welcoming you to our team!
Full-Time
, Temporary
PhD Project
Updated at
03/24/2025
While applying for the job please refer to jobvector
and use the following reference number:
Call2025-CC
