The UKB cares for around 500,000 patients per year, employs around 9,000 staff and has total assets of 1.6 billion euros. In addition to over 3,300 medical and dental students, a further 585 people are trained each year in numerous healthcare professions. The UKB is ranked first among university hospitals (UK) in NRW in the science ranking and in the Focus clinic list and has the third-highest case mix index (case severity) in Germany.
At the Institute of Pharmacology and Toxicology of the University Hospital Bonn, University of Bonn, working group Prof. Dr. Yongguo Li, the following full- time (38,5 h/week) positions Postdoc (m/f/d) and PhD student (m/f/d) are available as soon as possible:
Postdoc (m/f/d) and PhD student (m/f/d)(Thermogenic fat biology)
The contracts run till 31.12.2028 due the project with the prospect of extension.
The research group of Prof. Dr. Yongguo is specialized in the role of adipose tissue in metabolism and energy balance. The overarching objective of the lab is, combining molecular and systems biology, leveraging the most cutting-edge technologies and multidisciplinary approaches, to decipher fundamental mechanisms that drive fat tissue remodeling, metabolic adaptation, and thermogenesis, which play central roles in the regulation of energy homeostasis. Ultimately, we seek to unravel potential therapeutically targetable mechanisms and promising drugs, which have fundamental implications for achieving metabolic health and combating metabolic diseases such as obesity, diabetes, and cardiovascular diseases. Further information on our work: Bast-Habersbrunner EMBO Reports 2021, Li et al., Cell Reports 2019, Li et al., Cell 2018, Li et al., EMBO Reports 2014.
The successful candidates will employ various methods in molecular biology from basic cloning, analysis in cell culture, protein-biochemistry to Mass-Spec., RNA-Seq., ChIP-Seq, scRNA-Seq, high-resolution molecular imaging, genetic models as well as generation of further mouse mutant lines to devise a comprehensive molecular network that regulates white fat browning or a transformative molecular understanding of the cellular processes enabling physiological adaptation to thermogenic demand.
Key tasks and responsibilities:
- Designing, performing experiments and analyzing results
- Conceiving and developing new ideas, approaches or original technologies for studying gene regulation, fat metabolism and in general the lab’s research interests
- Generating and recording data, protocols and/or code for publication
- Drafting manuscripts and figures deriving from their own results
- Interacting with and supporting other laboratory members
- Sharing and discussing research results with key collaborators in the group, institute and among external collaborations
- Presenting scientific results in relevant international meetings
- For the postdoc position, project supervision, lab support/management
Requirements:
- Applicants should have a Master of Science (M.Sc.) or equivalent academic degree in a field related to the research area. Experience in some of the mentioned techniques is also advantageous
- For the postdoc position, a PhD in either biology, biophysics, biochemistry or other relevant disciplines. PhD experience in the field of genetics and epigenetics is appreciated but not mandatory
- Profound knowledge and research experience in molecular biology, biochemistry, cell biology and advanced cell culture experience
- Knowledge/willingness of mouse experiment
- Knowledge and interest in fat biology
- Independence and flexibility in terms of managing projects and new ideas
- Fluency in English
We provide:
- Responsible and versatile: a job with a lot of creative freedom in a collegial team
- A secure future: remuneration according to TV-L EG13
- Flexible for families: flexible working time models, the option of a place in the company daycare center and offers for those returning from parental leave
- Provision for later: company pension scheme
- Clever to work: option of an interest-free loan to purchase an e-bike
- Tailor-made training: subsidized further and advanced training
- A systematic start: structured induction
- Healthy at work: Numerous health promotion offers
- Employer benefits: Discounted offers for employees
We are committed to diversity and equal opportunities. Our aim is to increase the proportion of women in areas in which women are underrepresented and to promote their careers in particular. We therefore strongly encourage relevantly qualified women to apply. Applications will be treated in accordance with the State Equal Opportunities Act. We particularly welcome applications from suitable people with proven severe disabilities and persons with equivalent status.
Contact:
Do you meet our requirements and are you looking for a varied and challenging job? Do not hesitate and send your detailed application (preferably by e-mail in a file up to 5 MB in size) within four weeks quoting the job advertisement no. ST-26012, to:
Prof. Dr. Yongguo Li
Institut für Pharmakologie und Toxikologie
Universitätsklinikum Bonn
Venusberg-Campus 1
53127 Bonn
E-Mail: email
www.ukbonn.de
For more info about the lab, please see: https://www.pharmakologie.uni-bonn.de/en/research/li-lab
The positions are available immediately. The contracts run till 31.12.2028 with the prospect of extension. The positions are funded by the Emmy Noether Program of the DFG ( link ) and ERC Starting Grant ( link ).
