PhD position in Molecular Biology – Biology of Non-coding RNA

In the field of “Biology of Non-coding RNA” the research group of Prof. René Ketting offers the following PhD project:
Structure-function analysis of proteins involved in maternal transmission of RNA in zebrafish
We have identified a molecular platform for the loading of maternally provided RNA molecules (both mRNAs and piRNAs) into the germ cells of embryos. This platform does not consist of simple 1-1 interactions, but rather consists of multiple protein-protein and protein-RNA interactions that together result in a stable network, also named germ plasm. The germ plasm starts to be formed already in the oocyte, in a structure named the Balbiani body, and two proteins, Buc and Tdrd6, are essential components of this structure. We have identified a third protein, named Tdrd7, that interacts tightly with Tdrd6, and has been shown to affect germ plasm behavior in adults. This project will aim at structure-function studied in order to understand, at the atomic level, which interactions take place between Tdrd6, Buc and Tdrd7 on the one hand, and mRNAs on the other hand. In order to achieve this we will, in collaboration with the laboratory of Eva Wolf, determine 3-dimensional structures of isolated domains that are found within these proteins, and use these structures to assess function. Site directed mutagenesis will be used to create mutants that will be tested in vivo, in the zebrafish, in order to assess their relevance. Ultimately, we aim to develop a detailed interaction map of a number of critical germ plasm components, so that we can start to better understand how germ plasm works. Since germ plasm-related structures can be found in virtually all cell types, this knowledge will be relevant to many RNA-protein interaction networks that act in many different settings.
We offer
•          The possibility to work on a cutting-edge project using state-of-the-art technology in a highly motivated research team
•          A stimulating, diverse and international research environment
•          Advanced training opportunities
•          A competitive stipend
Required qualifications
•           Master or Diploma
•           Motivation to solve complex biological problems
•           Excellent communication skills
Starting date: 1 September 2016 or later
Duration of stipend: 3 years, with the possibility of extension
Deadline for applications (exclusively online via web form): 1 May 2016

How to apply:
Please apply exclusively via our online form at:
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While applying for the job please refer to jobvector and use the following reference number: JV-C10-RK1

About Institute of Molecular Biology gGmbH

Our International PhD Programme on the “Gene Regulation, Epigenetics and DNA Damage Response” gives talented and enthusiastic students the opportunity to undertake PhD research at the cutting edge of modern biology. Our groups cover a broad range of expertise and include leading biochemists, geneticists, cell and developmental biologists who study the molecular mechanisms of...

More about Institute of Molecular Biology gGmbH

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