PhD position in Molecular Biology - DNA demethylation, reprogramming & differentiation

In the field of “DNA demethylation and development” the research group of Prof. Christof Niehrs offers the following PhD project:
Developmental epigenetics in Xenopus embryos
Description:
In this project we will carry out a screen for novel epigenetic and demethylation regulators in Xenopus (frog) embryos, where microinjection yields facile access to functional analysis of gene function.
We will misexpress candidate epigenetic regulators by mRNA overexpression and antisense Morpholino injection to score for interesting developmental phenotypes. Candidate genes will then be studied by next generation sequencing, including genome-wide gene expression (RNA-seq) to monitor marker gene expression changes and DNA methylation (bisulfite-seq) analysis.  Further characterization of changes in embryonic gene expression will be followed up by genome wide ChIP-seq and bioinformatics analysis.  We will employ a systems biology approach for the understanding of the candidates gene function.  
We offer
•          The possibility to work on a cutting-edge project using state-of-the-art technology in a highly motivated research team
•          A stimulating, diverse and international research environment
•          Advanced training opportunities
•          A competitive stipend
 
Required qualifications
•           Master or Diploma
•           Motivation to solve complex biological problems
•           Excellent communication skills
 
Starting date: 1 September 2016 or later
Duration of stipend: 3 years, with the possibility of extension
Deadline for applications (exclusively online via web form):  1 May 2016

How to apply:
Please apply exclusively via our online form at:
https://www.imb-mainz.de/students-postdocs/international-phd-programme/apply-to-ipp/
Send application to
For further questions and contact information please check our website:
http://www.imb.de/PhD
While applying for the job please refer to jobvector and use the following reference number: JV-C10-CN3

About Institute of Molecular Biology gGmbH

Our International PhD Programme on the “Gene Regulation, Epigenetics and DNA Damage Response” gives talented and enthusiastic students the opportunity to undertake PhD research at the cutting edge of modern biology. Our groups cover a broad range of expertise and include leading biochemists, geneticists, cell and developmental biologists who study the molecular mechanisms of...

More about Institute of Molecular Biology gGmbH

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