PhD Position in Molecular Biology - Repair of structurally defined DNA lesions

In the field of “Repair of structurally defined DNA lesions” the research group of Dr Andriy Khobta offers the following PhD project:
Interactions of DNA modifications and DNA repair with gene transcription
An innovative experimental system, which exploits ad hoc reporter vectors containing structurally defined DNA base and/or backbone modifications of interest in precisely defined positions, will be used to investigate the modes of interaction of bulky lesions, such as cyclobutane pyrimidine dimers and adducts of chemical carcinogens, with the RNA polymerase II transcription initiation and elongation machineries. The aim is to understand how the structure of DNA lesions and their localisation with respect to functional gene elements define the efficiencies of repair and how important are these parameters for the repair pathway choice. The project tasks will be (i) detection and investigation of the fate of stalled RNA polymerase complexes; (ii) determination of the efficiencies of repair of structurally different DNA adducts; (iii) identification of specific NER components required for the removal of different DNA adducts and for the recovery of transcription. 

The postgraduate student will obtain training in molecular cloning, transfection of mammalian cells, gene expression analyses, flow cytometry, chromatin immunoprecipitation and RNA techniques. Previous experience in any of the listed techniques would be advantageous but is not strictly required. However, applicants should demonstrate knowledge of and adherence to general laboratory rules as well as sound understanding of the research topic..
We offer
•          The possibility to work on a cutting-edge project using state-of-the-art technology in a highly motivated research team
•          A stimulating, diverse and international research environment
•          Advanced training opportunities
•          A competitive stipend
  Required qualifications
•           Master or Diploma
•           Motivation to solve complex biological problems
•           Excellent communication skills
Starting date: 1 September 2016 or later
Duration of stipend: 3 years, with the possibility of extension
Deadline for applications (exclusively online via web form):  1 May 2016

Contact detail

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Job profile

Working hours
Contract duration
Type of job
PhD Project
Work experience
job experience is not required
Germany (Rheinland-Pfalz)
Working place
55128 Mainz
Area of expertise
Biology & Life Sciences

About Institute of Molecular Biology gGmbH

Our International PhD Programme on the “Gene Regulation, Epigenetics and DNA Damage Response” gives talented and enthusiastic students the opportunity to undertake PhD research at the cutting edge of modern biology. Our groups cover a broad range of expertise and include leading biochemists, geneticists, cell and developmental biologists who study the molecular mechanisms of...

More about Institute of Molecular Biology gGmbH

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