available as soon as possible)
Multiple sclerosis is a chronic inflammatory disease of the central nervous system which leads to progressive neurodegeneration and affects approximately 700,000 Europeans. Although the cause of multiple sclerosis is still not known, evidence suggest that it may be provoked by an immune response against self-antigens present in brain and spinal cord. Recent investigations identified B cells, a component of the adaptive immune system, and their products as important players in its immunopathogenesis. Removal of this cell type by treatment with specific drugs (anti-CD20 antibodies) reduces disease activity in many patients. However, emerging research suggests that not only CD20-bearing B cells, but also CD20-bearing T cells can be eliminated by this approach.
The project will focus on the role of different B and T cell subsets for pathogenesis and regulation of multiple sclerosis, especially in respect of treatment with anti-CD20 antibodies. The experiments will be performed in the multiples sclerosis mouse model ‘experimental autoimmune encephalomyelitis’, as well as in-vitro using primary cells. Among other techniques, flow cytometry, magnetic cell separation (MACS), ELISA and immunohistochemistry will be used.
We are looking for a highly motivated candidate with master´s degree (or equivalent) in biology, immunology, neuroscience or equivalent discipline. Experience in animal models of human diseases, cellular biology as well as molecular biology is desirable, but not mandatory.
We offer a TV-L 13 (50%) position for three years, beginning as soon as possible, in a well-equipped laboratory with profound expertise in the murine model of multiple sclerosis ‘experimental autoimmune encephalomyelitis’. All required models, techniques and reagents are established and readily available.
Applications should be addressed to Prof. Dr. Martin Weber, email: firstname.lastname@example.org.
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Institute of Neuropathology
University Medical Center Göttingen
37075 Göttingen, Germany
About Universitätsmedizin Göttingen
Das Institut für Neuropathologie der Unversität Göttingen ist einer der größten neuropathologischen Institutionen in Deutschland. Neben der gesamten Biopsie- und Autopsiediagnostik, Untersuchungen von Muskulatur und Nerven inklusive Enzymhistochemie und Elektronenmikroskopie hat die Abteilung folgende Forschungsschwerpunkte: Neuroimmunologie mit Schwerpunkt Multiple...More about Universitätsmedizin Göttingen