PhD student

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The Pro-Futura research group ‘Translational Neuroimmunology’ (headed by Prof. Dr. M.S. Weber) at the Department of Neuropathology, University Medical Center Göttingen has an opening for a

 
PhD student

 
(Salary according to TV-L (limited, part-time 50%)
available as soon as possible)


The project
The successful candidate will be an active member of the ‘Translational Neuroimmunology’ group at the Neuropathology (Director: Prof. Dr. W. Brück). The group is primarily investigating pathological as well as regulatory mechanisms of antigen-presenting cells during the development and progression of multiple sclerosis.

Multiple sclerosis is a chronic inflammatory disease of the central nervous system which leads to progressive neurodegeneration and affects approximately 700,000 Europeans. Although the cause of multiple sclerosis is still not known, evidence suggest that it may be provoked by an immune response against self-antigens present in brain and spinal cord. Recent investigations identified B cells, a component of the adaptive immune system, and their products as important players in its immunopathogenesis. Removal of this cell type by treatment with specific drugs (anti-CD20 antibodies) reduces disease activity in many patients. However, emerging research suggests that not only CD20-bearing B cells, but also CD20-bearing T cells can be eliminated by this approach.

The project will focus on the role of different B and T cell subsets for pathogenesis and regulation of multiple sclerosis, especially in respect of treatment with anti-CD20 antibodies. The experiments will be performed in the multiples sclerosis mouse model ‘experimental autoimmune encephalomyelitis’, as well as in-vitro using primary cells. Among other techniques, flow cytometry, magnetic cell separation (MACS), ELISA and immunohistochemistry will be used.

We are looking for a highly motivated candidate with master´s degree (or equivalent) in biology, immunology, neuroscience or equivalent discipline. Experience in animal models of human diseases, cellular biology as well as molecular biology is desirable, but not mandatory.

We offer a TV-L 13 (50%) position for three years, beginning as soon as possible, in a well-equipped laboratory with profound expertise in the murine model of multiple sclerosis ‘experimental autoimmune encephalomyelitis’. All required models, techniques and reagents are established and readily available.

Applications should be addressed to Prof. Dr. Martin Weber, email: martin.weber@med.uni-goettingen.de.
 
The University of Göttingen is an equal opportunity employer and places particular emphasis on fostering career opportunities for women. Qualified women are therefore strongly encouraged to apply. Applicants with disabilities and equal qualifications will be given preferential treatment.
 
 

Contact detail


How to apply:
Please send your application by email (pdf format) to Prof. Dr. Martin Weber.
Send application to
Prof. Dr. Martin Weber
Institute of Neuropathology
University Medical Center Göttingen
Robert-Koch-Str. 40
37075 Göttingen, Germany
martin.weber@med.uni-goettingen.de

 

Job profile


Working hours
Full-Time
Contract duration
Temporary
Type of job
PhD Project
Work experience
job experience is not required
Region
Germany (Niedersachsen)
Working place
37075 Goettingen
Area of expertise
Biology & Life Sciences, Healthcare & Public Health, Human medicine
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About Universitätsmedizin Göttingen

Das Institut für Neuropathologie der Unversität Göttingen ist einer der größten neuropathologischen Institutionen in Deutschland. Neben der gesamten Biopsie- und Autopsiediagnostik, Untersuchungen von Muskulatur und Nerven inklusive Enzymhistochemie und Elektronenmikroskopie hat die Abteilung folgende Forschungsschwerpunkte: Neuroimmunologie mit Schwerpunkt Multiple...

More about Universitätsmedizin Göttingen

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