PhD student position in Immunology in the Research Training Group GRK1727 at the University of Lübeck, Germany

Our Laboratory in the Institute for Systemic Inflammation Research ( www.isef.uni-luebeck.de ); from January 2017 in the new Institute for Nutrition Medicine ( http://www.uksh.de/Ernaehrungsmedizin_Luebeck ) at the University of Lübeck works on the development and function of antibodies. IgG antibodies are not only effector molecules of pathogenic and pro-inflammatory immune responses but can also be mediators of tolerogenic immune responses such as regulatory T cells. The inhibitory function is mediated through a specific kind of IgG Fc glycosylation. Our laboratory has discovered that antigen-specific sialylated IgG antibodies can be used to inhibit pro-inflammatory immune responses in an antigen-specific manner (Oefner et al, JACI 2012, 129(6):1647-1655; Karsten et al, Nature Medicine 2012, 18(9):1401-1406; Hess et al, JCI 2013, 123(9):3788–3796; Strait et al, Nature 2015, 517(7535):501-504). Now, we investigate how differentially glycosylated pro-inflammatory or immunosuppressive IgG antibodies develop and function in human and mice. To investigate these projects, we also produce our own monoclonal antibodies with different glyco-forms to investigate their potential in different autoimmune, allergy, vaccination and transplantation models.
For upcoming research projects we are looking for a highly motivated PhD student candidate. The PhD student will be part of the Research Training Group GRK1727 ( https://www.grk1727.uni-luebeck.de/grk1727 ).
Please contact Prof. Marc Ehlers (email: marc.ehlers@uk-sh.de) for further informations and application (via email). Deadline: extended 31.01.2017
 
How to apply:
via email: marc.ehlers@uk-sh.de
 
Send application to
Prof. Marc Ehlers
University of Lübeck
Ratzeburger Allee
23562 Lübeck
Germany
email: marc.ehlers@uk-sh.de
 
While applying for the job please refer to jobvector and use the following reference number: ME-01-2016

About Universität zu Lübeck; Deutschland;

Im ISEF (www.isef-luebeck.de) werden verschiedene Fragestellungen zur Bedeutung des Immunsystems für die Entwicklung von akut- sowie chronisch-entzündlichen Erkrankungen wie Autoimmunkrankheiten und Allergien bearbeitet.

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