PhD student positions in Immunology at the University of Lübeck, Germany

Our Laboratory of Immunology at the University of Lübeck works on the development and function of antibodies. IgG antibodies are not only effector molecules of pathogenic and pro-inflammatory immune responses but can also be mediators of tolerogenic immune responses such as regulatory T cells. The inhibitory function can be mediated through a specific kind of IgG Fc glycosylation.
Depending on the co-stimulus differently glycosylated IgG antibodies develop and mediate distinct effector functions via the classical Fcgamma reptors or suggar-binding receptors of the C-type lectin receptor family.
Accordingly, we also produce our own monoclonal antibodies with different glyco-forms to investigate their potential in different autoimmune, allergy, vaccination and tumor models.

Our laboratory has e.g. discovered that antigen-specific sialylated IgG antibodies can be used to inhibit pro-inflammatory immune responses in an antigen-specific manner.

Selected publications: Oefner et al, JACI 2012, 129(6):1647-1655; Karsten et al, Nature Medicine 2012, 18(9):1401-1406; Hess et al, JCI 2013, 123(9):3788–3796; Strait et al, Nature 2015, 517(7535):501-504; Epp et al, JACI 2018, 141 (1):399-402.e8; Bartsch et al, Front Immunol 2018, 9:1183.

For upcoming research projects to investigate:

- the potential of different vaccines and differently glycosylated IgG antibodies to fight against tumors or pathogens or
- the role of antibody glycosylation in allergy or
- the influence of nutrition and metabolitites on T and B cell and antibody responses

we are looking for highly motivated PhD student candidates.

Please contact Prof. Marc Ehlers (email: marc.ehlers@uksh.de ) for further informations and application (via email).
How to apply:
via email: marc.ehlers@uk-sh.de

Activities and responsibilities

You would also work with mice.

Qualification profile

We are looking for a highly motivated PhD student candidate. Experience with mice and flow cytometry would be good, but not essential.

Send application to

Prof. Marc Ehlers
Institute for Nutrition Medicine
University of Lübeck
Ratzeburger Allee
23562 Lübeck
Germany
email: marc.ehlers@uksh.de

While applying for the job please refer to jobvector and use the following reference number: ME-2019-05

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Im ISEF (www.isef-luebeck.de) werden verschiedene Fragestellungen zur Bedeutung des Immunsystems für die Entwicklung von akut- sowie chronisch-entzündlichen Erkrankungen wie Autoimmunkrankheiten und Allergien bearbeitet.
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