PostDoc Position in Translational Liver Research at University Hospital Dresden

 Technische Universität Dresden  Dresden
A 3-year postdoctoral research position funded by the BmBF is available by May 2016 in the Genomic Gastroenterology & Hepatology Group headed by Prof. Hampe at the University Hospital Dresden. The Hampe lab utilizes genomic methods to unravel the pathophysiology of gastrointestinal (GI) and liver disorders. We worked on adapting genomic methods (GWAS Buch et al. Nat Genet. 2015, translational profiling, Fritsch et al. Gen. Res. 2012, epigenetic profiling, Horvarth at al. PNAS 2014, Ahrens et al. Cell Metab. 2013, LCM-transcriptomics) to understand pathophysiology from human biopsy material. The functional translation will be performed jointly with the mechanistically focused Zeissig lab (Olszak et al., Nature 2014, Zeissig et al., Nat. Med. 2012) at CRTD (Center for Regenerative Therapies Dresden) that is part of the GI department.

  • MBOAT7 as a disease driver in liver cirrhosis. The group identified Membrane Bound O-Acyltransferase Domain Containing 7 (MBOAT7) in genome wide association study as susceptibility gene for alcoholic liver cirrhosis (Buch et al. 2015, Nat. Genet). In follow up studies we were able to show that the mutation leads to a lower expression of the gene. MBOAT7 is a lysophosphatidylinositol acyltransferase that has specificity for arachidonoyl-CoA as an acyl donor. Increased availability of arachidonic acid may lead to increased inflammatory signaling by prostaglandins. Possible direction of the project: Analysis of MBOAT7 KO mice under different NASH/NAFLD diet to identify the eicosanoid spectra and the inflammatory network in cirrhotic liver.
  • Innate immunity zonation in the liver. The liver shows a remarkable uniform anatomical structure composed of the regular arrangement of mainly hexagonal lobules in a honey comb-like pattern. By the use of LCM-RNA Seq we analyzed hepatozytes from the central vein periportal field. We were able to reproduce the already known metabolic, WNT-signalling and oxygen gradient from the central vein to the portal field. In addition we identified an innate immunity zonation. The function of this zonation is totally unknown and will know be functionally investigated by the use of genetically engineered animal models.
Profile of the Candidate/Requirements:
  • Successful PhD in Molecular and Cell Biology or other related fields
  • Highly self-motivated with a genuine interest in liver metabolism and immunity
  • Experience in setting up, analyzing and manipulating in vivo rodent models

We offer:
  • Projects that aim to understand the mechanisms of disease using targets of proven relevance based on patient material
  • A position in a well-equipped and international research environment on the Dresden biomedical campus, which harbors several state-of-the-art facilities (lipidomics, CRISPR, MPI-CBG).
  • Our work is embedded in the University Hospital Dresden and Center for Regenerative Therapies Dresden - CRTD, an interdisciplinary base for innovative research.
  • A contract which is limited for three years initially. The contract conditions and the salary will be according to the collective labour agreement for public service employees of the federal states of Germany (TV-L E13)

How to apply:
Candidates are encouraged to send their application (English or German) including CV, list of publication, a short description of research experience and interests, and the contact details of two references per e-mail to:
Send application to
Prof. Dr. Jochen Hampe
Bereich Gastroenterologie & Hepatologie
Medizinische Klinik 1
Universitätsklinikum Dresden
Fetscherstr. 74
Tel.: +49 (351) 458-5643
Fax.: +49 (351) 458-7236
While applying for the job please refer to jobvector and use the following reference number: 0000

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