Senior Research Associate / Lab Technician in CNS Pharmacology / Neurobiology

 Actelion Pharmaceuticals Schweiz  Basel
Senior Research Associate / Lab Technician in CNS Pharmacology / Neurobiology About the Company

Actelion Ltd. is a leading biopharmaceutical company focused on the discovery, development and commercialization of innovative drugs for diseases with significant unmet medical needs.
Actelion is a leader in the field of pulmonary arterial hypertension (PAH). Our portfolio of PAH treatments covers the entire spectrum of care, from WHO Functional Class (FC) II through to FC IV, with oral, inhaled and intravenous medications. Actelion is also offering treatments for a number of specialist diseases including Type 1 Gaucher disease, Niemann-Pick type C disease, Digital Ulcers in patients suffering from systemic sclerosis, and mycosis fungoides in patients with cutaneous T-cell lymphoma.
Founded in late 1997, with now over 2,400 dedicated professionals covering all key markets around the world  including the US, Japan, China, Russia and Mexico. Actelion has its corporate headquarters in Allschwil / Basel, Switzerland.
Actelion shares are traded on the SIX Swiss Exchange (ticker symbol: ATLN) as part of the Swiss blue-chip index SMI (Swiss Market Index SMI®). All trademarks are legally protected.

Job Responsibilities
  • Design and conduct pharmacological studies in rat and mouse models of neurodegeneration based on viral vector-mediated, genetic and pharmacological approaches to evaluate the neuroprotective potential of novel CNS drug candidates
  • Perform behavioral assessments on clinically relevant, neurological readouts (e.g. motor function and cognition)
  • Measure physiological parameters such as heart rate, body temperature, electromyography
  • Dose animals (po, ip, sc)
  • Prepare biological samples (brain, spinal cord, muscle, cerebrospinal fluid, blood)
  • Assess biomarkers with different analytical methods (e.g., ELISA, RIA, Western blot, qRT-PCR)
  • Perform surgeries (e.g., stereotaxic surgery, implantation of osmotic mini-pumps and telemetry transmitters) in rats and mice
  • Efficiently plan, analyse, document and present experiments in a multidisciplinary environment
  • Proactively drive the setup, evaluation and validation of new models and techniques
  • Oversee and actively manage the breeding of transgenic mouse/rat colonies at an external contract research organization

Candidate Requirements
  • Apprenticeship as a lab technician in biology/biochemistry and/or Master degree in Science; specialized education in Neuroscience or Immunology as a plus; Researchers holding a PhD will generally not be considered because the advertised position has a strong focus on actual practical lab work
  • Theoretical knowledge and working experience of > 3 years in at least one of the following fields: Neuromuscular disorders, Lysosomal storage diseases, Huntington's disease, Parkinson's disease; candidates with a strong background in animal models of Psychiatry will also be considered
  • Solid hands on experience in rodent behavioural pharmacology (motor function and cognitive testing), stereotaxic surgery, brain, spinal cord or nerve dissections, ex vivo tissue analysis (e.g., Immunohistochemistry, Western blotting, qRT-PCR, ELISA)
  • Willingness to work with viral vector (AAV or lentivirus) technology
  • Strong drive to solve experimental challenges with an eye for technical details
  • Proven ability to independently perform, analyze and accurately document experiments
  • Flexible, pro-active and motivated to contribute to the development of novel drugs
  • Excellent knowledge of English (verbal and written), additional knowledge of French or German is considered a plus
  • Good communication skills in a multicultural environment
  • Previous experience in managing external contract research studies is considered an advantage

What Actelion Offers
  • A competitive salary and generous social benefits
  • The possibility for development and advancement within our dynamic organization 
  • The innovative and stimulating atmosphere of a multicultural environment

The research facilities are located in Allschwil, Switzerland, a suburb of Basel on the borders of France and Germany.

How to apply:
Please apply via the "apply now" button
Send application to
Gewerbestrasse 16
Allschwil Basel 4123
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