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Identification and characterization of a microcin from E. coli and effects on other bacteria and on biofilms

Master Thesis Project at the Brandenburg University of Technology Cottbus–Senftenberg

The InnoProfile-Transfer research groups “Image-based assays” and “Multiplex-Bead-Assays” (Peter Schierack, Stefan Rödiger, Claudia Liebsch) at the Brandenburg University of Technology Cottbus – Senftenberg in Senftenberg offer the opportunity to carry out a Master thesis projects within an interdisciplinary project with strong foundations in both basic and applied research. We have an intense collaboration with small and medium-sized businesses. Our groups focus on the development of novel and innovative multi-parameter assays for life sciences and diagnostics. The scope of our working groups is deliberately broad covering
  • Medical and Environmental Microbiology,
  • Cell biology,
  • Development of screening assays,
  • Multiparameter biomolecule detection (small nucleic acids, proteins, …),
  • Microbead-based assays,
  • Statistical Bioinformatics (digitial PCR, multiplex microbead assays, …),

The foundation of our work is a highly versatile microscope imaging technology platform for the multiplex real-time detection of biomolecules and autoimmune antibodies.

For more information please see:

Project topic:
“Identification and characterization of a microcin from E. coli and effects on other bacteria and on biofilms.”

Microcins are very small proteins consisting of a few peptides, which belong to the group of bacteriocins. They are produced by enterobacteria, mainly Escherichia coli , and show bacterial activity against closely related species. Microcins could serve as an alternative for classical antibiotics and could be used in the therapy of infectious diseases, which are caused by highly resistant pathogens. In a previous study we found a strong microcin-producing E. coli from a wild bird which has to be detailed characterized.

  • Screening for microcin production of other E. coli
  • Biofilm assays
  • Infection assays: Infection of mammalian cell lines with bacteria
  • Microscopy: adjusting our fluorescence microscopy technology to biofilm screening
  • Characterization of microcins: molecular biology methods (cloning, sequencing, ...)

  • Study of biology, biomedicine, biotechnology, biochemistry or related subject
  • Interest in natural sciences
  • Personal initiative and the skills for self-organization and for independent work

  • From summer/autumn 2014

  • You will receive a monthly financial support

Contact detail

How to apply:
Please apply by e-mail
Send application to
For your application and further information please contact Dr. Stefan Rödiger or Prof. Peter Schierack.

Job profile

Working hours
Contract duration
Type of job
Diploma Thesis/Master's Thesis
Work experience
job experience is not required
Germany (Brandenburg)
Working place
01968 Senftenberg
Area of expertise
Biology & Life Sciences, Biotechnology, Human medicine