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Research Fellow, Master's / Diploma Level

Our laboratory aims to identify and study genes that protect key organs such as the developing brain from low oxygen stress (hypoxia), a major cause of cerebral palsy and seizure disorders. We combine genome-wide techniques with model organism studies in the zebrafish and mouse with the goal of discovering novel therapeutic targets to help prevent irreversible brain injury. 
     We have established and optimized an embryonic zebrafish model to study protection against hypoxic injury in detail using a functional genomic approach. Using this developmental zebrafish model, we validated five novel hypoxia-protective genes from hundreds of hypoxia-regulated genes we identified via differential expression microarray: irs2, crtc3, and camk2g2 have been previously implicated in insulin and glucose metabolism, while btr01 and ncam2 are previously uncharacterized. These results extend our understanding of the mechanisms of hypoxic preconditioning and affirm the discovery potential of this novel vertebrate hypoxic stress model (see recent publications below). Candidates will receive training in performing the follwing types of experiments: 

a) Molecular Biology
b) Biochemistry
c) Tissue/Cell Biology
d) Immunology
e) Histology

Candidates will be expected to plan and execute detailed experiments, prepare research plans and assist in the development of new techniques, record and interpret results, create spreadsheets, process specimens for in-lab and outside-lab analysis, and prepare reagents and stock solutions.

The lab currently contains scientific and medical postdoctoral fellows, undergraduates, and technicians. A comitment of 6-12 months is preferred. We are a "work hard, play hard" environment in lovely San Diego and are surrounded by the natural beauty of the  ocean, desert, and mountains, as well as the rich scientific environment at the University of California, San Diego. We look forward to your interest and candidacy.

Selected publications:
Manchenkov T, Pasillas MP, Haddad GG, Imam FB. Novel Genes Critical for Hypoxic
Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism. G3 (Bethesda). 2015 Apr 3;5(6):1107-16. doi: 10.1534/g3.115.018010. PubMed PMID: 25840431.

Woods I, Imam FB. Transcriptome analysis of severe hypoxic stress during development in zebrafish.
Genomics Data. September 2015, in press.

Contact detail

How to apply:
Please send curriculm vitae and 1-paragraph Personal Statement to the email address provided.
Send application to
Department of Pediatrics, Division of Neonatology
UCSD School of Medicine, Health Sciences
Biological Research Facility II, Room 2117
9500 Gilman Drive, Mail Code: 0734
San Diego, CA, 92093

Job profile

Working hours
Contract duration
Type of job
Diploma Thesis/Master's Thesis
Work experience
job experience is not required
United States
Working place
92093 University of California, San Diego
Area of expertise
Biology & Life Sciences, Human medicine