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4 PhD positions (f/m) in the DFG-funded Research Training Group 1739 (GRK1739)

The University of Duisburg-Essen is one of the youngest universities in Germany and thinks in terms of possibilities, not limitations. In the heart of the Ruhrregion, we develop ideas of the future at our 11 faculties. We are strong in research and teaching, live diversity, support potential and are highly committed to an educational equality that has earned this name.
The University of Duisburg-Essen offers within the
DFG-funded Research Training Group 1739 (GRK1739)
4 PhD positions (f/m)
 (salary according TV-L E13 65%)
The GRK1739 “Molecular determinants of the cellular radiation response and their potential for response modulation” offers outstanding interdisciplinary scientific training and research opportunities for graduates of life sciences and medicine with interest in basic and translational research. Actually we offer 4 PhD positions focussing on the eradication of clonogenic tumor cells. Ionizing radiation induced cell inactivation involves apoptosis, necrosis, mitotic catastrophe, senescence and autophagy. A complex network of survival and death pathways controls cell-fate decisions downstream of the critical insult, and this network can be exploited for a modulation of radiation responses. The impact of individual tumor cell-specific changes on the cell death mode and on the efficacy of ionizing radiation will be studied in vitro and in vivo in relevant models reflecting tumor heterogeneity by using appropriate end-points. In the individual projects different aspects are investigated using genetic, biochemical and pharmacologic approaches to analyze the connected roles of
  • Asm (Project of Prof. E. Gulbins),
  • AKT (Project of Prof. V. Jendrossek),
  • HIF-1 and HIF-2 (Project of Prof. E. Metzen),
  • defined oncogenes and tumor suppressor genes that are deregulated in non-small cell lung cancer (Project of Prof. M. Schuler),
in the cross-talk between radiation-induced DNA damage and membrane damage, DNA repair, and cell fate upon irradiation with photons, or in selected cases protons.
More details about the individual projects and the research training group can be found at: http://www.uni-due.de/med/forschung/grk1739/index.shtml
Applicants should hold a Master Degree or equivalent in e.g. Molecular Biology, Biochemistry, Biophysics, or Cell Biology. Candidates are selected on the basis of excellent performance in their studies and their motivation. The positions will start in April 2015 for three years.
Please send the filled in application form (which can be found at: https://www.uni-due.de/med/forschung/grk1739/jobs.php) together with a cover letter, your CV and degree certificates as one pdf-file until October 30, 2014 to:
Dr. Gabriele Siedenburg
Scientific Coordination Research Training group 1739       
E-Mail: gabriele.siedenburg@uni-due.de
Incomplete applications or submissions directly sent to the principal investigators cannot be considered. Interviews will be presumably held from December 8-9, 2014.
The University Duisburg-Essen aims at promoting the diversity of its members (see http://www.uni-due.de/diversity/international.shtml). Applications from disabled or equivalents according to § 2 Abs. 3 SGB IX are encouraged.
The University Duisburg-Essen has been awarded for its effort to promote gender equality with the "Total-E-Quality-Award". It aims at increasing the share of women in the scientific personnel and therefore explicitly encourages women to apply. Women will be preferentially considered when equally qualified according to the state equality law.

Contact detail

How to apply:
Please follow the instruction guidelines in the announcement.
Send application to
Dr. Gabriele Siedenburg
Institute for Cell Biology (Cancer Research)
Virchowstr. 173
45122 Essen

E-Mail: gabriele.siedenburg@uni-due.de
Homepage GRK1739:

Job profile

Working hours
Contract duration
Type of job
PhD Project
Work experience
job experience is not required
Germany (Nordrhein-Westfalen)
Working place
45122 Essen
Area of expertise
Biology & Life Sciences, Human medicine