Novel Key Regulators of Glucocorticoids in Inflammation and Bone disease

The Tuckermann Lab at the Institute for Comparative Molecular Endocrinology/Ulm University
(Director: Prof. Dr. Jan Tuckermann) is looking for a PhD student studying molecular mechanisms
of glucocorticoid receptor actions in inflammation and bone disease in vivo.
Glucocorticoid hormones such as cortisone are potent anti-inflammatory drugs and are
therefore widely used to treat inflammatory and autoimmune diseases. But the usefulness of
glucocorticoid therapy is hampered by severe side effects such as diabetes and osteoporosis.
In particular osteoporosis is becoming one of the most prevalent diseases in the ageing society.
Our research interests focus on the cellular and molecular mechanisms of the glucocorticoid
receptor (GR) underlying the beneficial and the adverse glucocorticoid actions in inflammation,
metabolism and osteoporosis (PNAS (2011) 108:19317, Cell Metabolism (2010) 11:517, Nature
Reviews Rheumatol (2012) 8:654), Mol Cell Endocrinol (2013) 380:108), Genome Research
(2015 in press).
We identified novel hitherto unknown mechanisms of the GR to regulate inflammation and
novel regulatory genes that are involved in GR action on bone mass and thus provide potential
new drug targets to combat osteoporosis.
The project consists of in-depth analysis of these novel regulators in models of inflammation,
inflammatory bone disease in transgenic mouse models in vivo. It involves a broad range of
state-of-the-art techniques: cell biological, molecular biological techniques, viral gene delivery
as well as histological methods, lineage tracing and micro computer tomography
measurements in conditional knock out mice.
The successful candidate has a broad knowledge in cell and molecular biology and a genuine
interest in understanding molecular mechanisms of differentiation processes involved in
inflammation and/or organ integrity using in vivo approaches in transgenic mouse models. We
expect a highly motivated ambitious student ready for scientific challenges in this project relevant
for osteoporosis and inflammation affecting an ageing society.
We offer an enthusiastic international team and the position is embedded in the International
Graduate School in Molecular Medicine in Ulm with courses in state-of-the-art techniques and
soft skills and support for conference visits.
The position starts from August 1st 2015 on a salary level according to TVLE13 (65%) and is
restricted to initial 2 years with extension upon evaluation.
Applicants are invited to apply by sending a letter of interest, CV and contact details of two referees
in a single PDF file by email to: jan.tuckermann@uni-ulm.de latest June 7th 2015.
Prof. Dr. Jan Tuckermann; Institute of Comparative Molecular Endocrinology; Ulm University,
89081 Ulm
Further information about the lab can be found at: http://www.uni-ulm.de/nawi/nawi-bio1.html

How to apply:
jan.tuckermann@uni-ulm.de 
Prof. Dr. Jan Tuckermann; Institute of Comparative Molecular Endocrinology; Ulm University,
89081 Ulm
Send application to
jan.tuckermann@uni-ulm.de latest June 7th 2015.
Prof. Dr. Jan Tuckermann; Institute of Comparative Molecular Endocrinology; Ulm University,
89081 Ulm
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About Universität Ulm

Das Institut für Molekulare Endokrinologie der Tiere hat als Kernaufgabe die Erforschung der Wirkung von Hormonen auf mesenchymale Stammzellen während entwicklungsbiologischer Abläufe, bei der Erhaltung der Gewebeintegrität und bei der Wechselwirkung mit dem Immunsystem. Mit einem besseren Verständnis der (Fehl-)-Regulation dieser Prozesse durch Hormone...

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