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PhD Position

The Biochemistry group at the Carl von Ossietzky University Oldenburg (Department of Neuroscience), offers a
PhD-position for three years
(TVL E13/50%)
in the research project "Control of the guanylate cyclase signaling unit in phototransduction by the RD3 protein” funded by the Deutsche Forschungsgemeinschaft (DFG). The position is supposed to start in January 2015 and should lead to a successful dissertation.

The overall aim of the project is to gain a deeper understanding of the molecular mechanisms leading to retinal degeneration involving the RD3 protein and its mutual dependencies with the guanylate cyclase complex. In particular, we plan to investigate how the RD3 protein interacts with dystrophy relevant mutants of guanylate cyclase, whether it stabilizes structurally labile forms of some of these mutants, and how it controls their trafficking out of the endoplasmic reticulum. Furthermore, it is planned to investigate how constitutively active mutants of the guanylate cyclase activator GCAP1, which cause cone dystrophies, are influenced by co-expression of and association with the RD3 protein. Finally, the molecular and protein-chemical properties of the RD3 protein itself are not well understood and the project will further focus on structure-function relationships of RD3 and RD3 mutants.

From a successful candidate we expect an above-average academic university degree (e.g. Master) in Biology, Chemistry, Biochemistry or related subjects and a strong interest in basic research in a collaborative research environment. We require very good mastering of English reading and writing. Our group is located at the Carl von Ossietzky University, Germany and is part of several collaborative centres of excellence including the Research Training Group (RTG) “Molecular Basis of Sensory Biology”. These collaborations will give you access to a very wide range of superb modern equipment, techniques and expertise. You will become part of a larger team working closely together on related questions. For more information about our group, see http://www.biochemie.uni-oldenburg.de/.

The Carl von Ossietzky University of Oldenburg is an equal opportunity employer and seeking to increase the proportion of female academic staff members. According to § 21, 3 NHG female applicants are to be preferentially considered in case of equal qualification. Applicants with disabilities will be preferentially considered in case of equal qualification.


Contact detail

How to apply:
Please send your application (CV, letter of motivation, list of publications, certificates) to Prof. Karl-Wilhelm Koch.
Application by email as a single pdf file is preferred.
Applications must be submitted by October 31, 2014
Send application to
Carl von Ossietzky University Oldenburg, Prof. Dr. Karl-Wilhelm Koch, Faculty VI, Biochemistry group, Carl-von-Ossietzky-Str. 9-11, D-26129 Oldenburg, Germany
or electronically to karl.w.koch@uni-oldenburg.de.

Job profile

Working hours
Contract duration
Type of job
PhD Project
Work experience
job experience is not required
Germany (Niedersachsen)
Working place
26111 Oldenburg (Oldb)
Area of expertise
Biology & Life Sciences, Chemistry