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PhD position in Molecular Biology - Epigenetic gene regulation acute myeloid leukaemia

In the field of  “Epigenetic gene regulation acute myeloid leukaemia” the research group of Prof. Thomas Kindler offers one PhD project.

In this project we aim to understand the specific role of mutant FLT3 (FLT3-ITD) on epigenetic gene regulation. We will make use of several well characterized human AML cell lines and generate syngeneic cells expressing either wild-type FLT3 or FLT3-ITD. The PhD student will perform global gene expression profiling by RNA-sequencing, histone modifications will be investigated by ChIP-Seq analyses. Further, FLT3-ITD expressing cells will be treated with specific FLT3-inhibitors and their effects on global chromatin modification will be analysed. FLT3-ITD-dependent histone modifications and involved epigenetic regulators will be further characterized by immunoblot analysis, ChIP and shRNA-mediated gene knockdown allowing us to identify FLT3-ITD-specific epigenetic targets. Finally, promising therapeutic strategies will evaluated at the leukemic stem cell level using a well-established murine Flt3+/ITD:Dnmt3afl/fl:Mx1-Cre+ leukemia model. 

We offer
•    The possibility to work on a cutting-edge project using state-of-the-art technology in a highly motivated research team
•    A stimulating, diverse and international research environment
•    Advanced training opportunities
•    A competitive stipend

Required qualifications
•    Master or Diploma
•    Motivation to solve complex biological problems
•    Excellent communication skills

Starting date: October 2015 or later
Duration of stipend: 3 years, with the possibility of extension
Deadline for registration (exclusively online via web form):  20 June 2015

Contact detail

How to apply:
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Job profile

Working hours
Contract duration
Type of job
PhD Project
Work experience
job experience is not required
Germany (Rheinland-Pfalz)
Working place
55128 Mainz
Area of expertise
Biology & Life Sciences, Pharmaceutics