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PhD position in Voltage clamp fluorometry

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This biophysical project aims at the identification of structure function relationships of P2X receptors by voltage clamp fluorometry (Lörinczi et al. PNAS, 2012). P2X Receptors are a class of ATP-gated ion channels that are becoming increasingly important as drug targets. First crystal structures have been resolved and revealed some unique molecular properties. In this research project we aim to investigate the molecular basis of P2X receptor activation and define their interaction with different ligands as a basis fort the development of new drug targeting strategies and the design of functionally altered receptor mutants with novel properties.

We are looking for a highly motivated person with enthusiasm for basic science and a good back­ground in molecular biology. Interest in protein structures, experience in electro­physiological and/or fluorescence measurements, non-natural amino acids, and  Xenopus oocyte expression is an advantage. The ability to independently and responsibly plan and perform experiments and to work in a multidisciplinary team is expected.

Contact detail

How to apply:

Please send your application including a letter of motivation, CV, certificates, and references until Sept. 21, 2014.

Send application to

Prof. Dr. Annette Nicke

Walther-Straub-Institut für Pharmakologie und Toxikologie

Nussbaumstr. 26

80336 München


Job profile

Working hours
Contract duration
Type of job
PhD Project
Work experience
job experience is not required
Germany (Bayern)
Working place
80336 München
Area of expertise
Biology & Life Sciences, Pharmaceutics, Physics