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PhD position to study the mechanism and functional crosstalk of posttranslational modifications

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We invite applications for a PhD position in the research group of Dr. Sonja Lorenz at the Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg.
The successful applicant will have the opportunity to enroll in the ‘Graduate School of Life Sciences’ in Würzburg – a prestigious international graduate program funded by the German Excellence Initiative.
The PhD position is funded by the Emmy Noether Program of the German Research Foundation (DFG) to explore the molecular mechanisms of ubiquitination reactions. The specific aim is to elucidate how the ubiquitination machinery is regulated and how it crosstalks with other types of posttranslational modifications. The lab combines structural biology (X-ray crystallography, NMR spectroscopy) with biophysical, biochemical, and cell biological analyses. Depending on individual qualifications and interests, the successful applicant will have the opportunity to gain experience in various aspects of this multidisciplinary approach.
The Lorenz lab has access to state-of-the-art instrumentation in X-ray crystallography, high-field solution NMR spectroscopy, biophysics and an extensive range of modern biochemical, and cell biological equipment. The Rudolf Virchow Center is integrated into a stimulating, collaborative research environment that includes the Biocenter, the Research Center for Infectious Diseases, various institutes of the university hospital, and the Max Planck Research Group for Systems Biology in Würzburg.
Applicants should have a M.Sc./diploma in molecular biology, biochemistry, biophysics, or a related discipline and a strong interest in enzyme mechanism and structure-function studies on proteins. Experience in basic cell biological techniques is desirable. Additional skills in protein expression and purification, biophysical or structural techniques would be beneficial. Good English language skills are essential; knowledge of German is not required.
The position will start on 1 October 2014 or later, upon mutual agreement, and is initially available for 3 years. Salary will be according to German TVL scale. In case of equivalent qualifications, disabled applicants will be preferentially considered.
Applications and informal queries should be sent to Sonja Lorenz by email (sonja.lorenz@virchow.uni-wuerzburg.de). Applications are expected to include a letter of motivation detailing research interests and expertise, a CV, and the contact information for at least two references. Review of applications will begin immediately.
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Contact detail

How to apply:
by email
Send application to
Sonja Lorenz, PhD
Rudolf Virchow Center for Experimental Biomedicine
Josef-Schneider-Strasse 2, Haus D15
97080 Würzburg


Job profile

Working hours
Contract duration
Type of job
PhD Project
Work experience
job experience is not required
Germany (Bayern)
Working place
97080 Wuerzburg
Area of expertise
Biology & Life Sciences