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PhD research position

The RADIATE consortium is an EU wide research project to advance our understanding of radiobiology to open novel routes for effective therapeutic intervention with biological targets to improve the outcome of cancer treatment. RADIATE will investigate two specific areas: 1) radioresistance of the tumor and the sensitivity of surrounding normal tissue, and 2) the effects of the tumor microenvironment leading to greater overall resistance and altering the immune response to the tumor.

The Department of Molecular Cell Biology at the Institute of Cell Biology (Cancer Research) of the University of Duisburg Essen, Medical School (Head Prof. Dr. Verena Jendrossek) invites applications for a temporary
 
PhD research position

available in a RADIATE project about the

Molecular determinants of the antineoplastic action of membrane-targeted lipid modifying drugs.

Cellular membranes are important integrators of extrinsic growth, survival and death signals originating from the microenvironment. They provide platforms for the activation of intracellular signaling cascades and are a source for lipid second messenger molecules that participate in the regulation of the DNA damage response and cell fate. We showed that modulation of membrane lipids by synthetic phospholipid analogs triggers cell death in solid human tumor cells due to disturbance of integrin-mediated survival signals. Moreover, they increased the efficacy of ionizing radiation. Interestingly, long-term treatment with such drugs resulted in the selection of drug-resistant cancer cells characterized by increased sensitivity to ionizing radiation. In this project we aim to further define the mechanisms of the antineoplastic actions of Erufosine in malignant cancer cells, investigate the mechanisms and the contribution of drug-induced changes in tumor cell-stroma interactions to increased efficacy of in combination with radiotherapy, and identify the assumed unique molecular changes initiated by long-term drug exposure that increase tumor cell sensitivity to ionizing radiation. These investigations shall provide a molecular basis for the identification of novel targets for modulating tumor cell survival and host-mediated resistance to radio(chemo)therapy and for the design of effective combination therapies. [Literature: Chometon G. et al., Anticancer Agents in Med Chem 14:578-91 (2014); Henke G. et al. Radiat Oncol 7:172f (2012); Jendrossek V. Current Pharm Biotechnol 13:1426-38 (2012); Rudner J. et al Radiat Oncology 5:108 (2010); Handrick et al., Radiother Oncol 80, 199-206 (2006); Jendrossek V. et al., Oncogene 22, 2621-31 (2003)]

We are looking for highly motivated young researchers with a strong interest in interdisciplinary research projects in cell/tumor biology and a Diploma or a Master degree in biochemistry, biology or molecular medicine. You will have the opportunity to perform your PhD in an excellent and supporting scientific environment within the framework of the structured PhD program of the EU ITN RADIATE. Good knowledge and practical expertise of current cell and molecular biology techniques as well as hands-on experience with radiation biology methods and/or animal experiments is highly desired. For further information please visit:
https://www.unidue.de/zmb/members/jendrossek/overview.shtml.

Please consider the following eligibility criteria for EU projects: Early Stage Researchers must not have spent more than 12 months out of the past 36 months (prior engagement) in the country of the host organization.

Interested scientists please send their application (CV, academic record, research interests and indication of two referees) via E-mail in a single pdf-file to verena.jendrossek@uni-duisburg-essen.de.

Contact detail


How to apply:
Interested scientists please send their application (CV, academic record, research interests and indication of two referees) via E-mail in a single pdf-file to verena.jendrossek@uni-duisburg-essen.de.
Send application to
Prof. Verena Jendrossek
University of Duisburg-Essen, Medical School
Institute of Cell Biology (Cancer Research)
Department of Molecular Cell Biology
Virchowstr. 173
45122 Essen
Germany

E-Mail: verena.jendrossek@uni-duisburg-essen.de

Job profile


Working hours
Full-Time
Contract duration
Temporary
Type of job
PhD Project
Work experience
job experience is not required
Region
Germany (Nordrhein-Westfalen)
Working place
45122 Essen
Area of expertise
Biology & Life Sciences, Pharmaceutics
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