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PhD Student (Biochemistry)

 Radboud University Medical Center  Nijmegen
For the project “Redox Control of the Active/Deactive Regulation of Mitochondrial Complex I” within the Priority Program „Dynamics of Thiol-based Redox Switches in Cellular Physiology” (SPP 1710: of the German Research Foundation (DFG), the Nijmegen Center for Mitochondrial Disorders (, The Netherlands is looking for a
PhD Student (Biochemistry)
The Project aims at understanding the molecular mechanism of the active/deactive transition of mitochondrial complex I and how it is controlled by modification of the cysteine in subunit ND3. We will use our recently solved X-ray crystallographic structure of mitochondrial complex I that suggests significant structural changes between the A- and D-from of complex I around its cysteine switch, to build structural models of the two states based on Molecular Dynamics simulations. This information will be used to guide a mutagenesis study aimed at identifying the protein domains and residues critically involved in the A/D transition in order to understand the structural changes associated with this process at the atomic level. In a second part of the project we will study how the A/D transition and the associated cysteine switch is controlled depending on the functional state of mitochondria. For this we will develop a quantitative redox-proteomic strategy to address the A/D transition state and the status of the associated cysteine switch in mitochondria and cells.
We expect a grade in Biochemistry, Biology, Chemistry or Molecular Medicine. Experience in the field of Biochemistry and Proteomics, especially of membrane protein ­complexes is a plus. The successful candidate will be fluent in English and show enthusiasm, a proactive attitude, and will enjoy working in a team.
We offer a highly attractive research environment in a strong and internationally renowned team.
Please send your email application including a letter of intent, a curriculum vitae, certificates, letters of recommendation and references to Prof. Dr. Ulrich Brandt ( Application deadline: August 15, 2015
How to apply:
Please apply by Email with a letter of intent, your CV and copies of relevant certificates.
Send application to
Prof. Dr. Ulrich Brandt
While applying for the job please refer to jobvector and use the following reference number: 150706

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