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PHD student - biotechnology, bioinformatics

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Job description:
The candidate will be involved in the identification of human genetic factors predisposing to the common inflammatory oral disease periodontitis (PD). She/he will initially participate in a genome-wide association study (GWAS) of aggressive periodontitis (AgP), the most severe and early-onset phenotype of PD. Follow-up studies will include meta-analyses of GWAS of PD and coronary artery disease (CAD), and PD and rheumatoid arthritis (RA) to identify shared pleiotropic risk loci.
The PhD student should be highly interested in modern human genetic questions and should have a good general knowledge of genetics. Skills in programming languages or statistical programms (R or others) would be of advantage. We provide state-of-the-art laboratories and methodologies, an excellent scientific education, and an individual supervision in a young and motivated team. The duration of the project is scheduled for 3 years.
 
Details:
PD is an inflammatory disease of the oral cavity caused by bacterial biofilm on the teeth and gingiva. 50% of the general population is affected by some form of PD. Epidemiological studies demonstrated an association with CAD and RA and a causal role of PD on the development of CAD and RA is discussed. During the last years, we could identify the first known shared risk genes of PD, CAD and RA. The PhD project will be endowed with recently generated genotypes of the worldwide largest analysis case-control sample of AgP as well as with genotypes of several large GWAS of CAD and RA. The project is a collaborative project of the Institute of Integrative and Experimental Genomics (IIEG) in Lübeck, Schleswig-Holstein and the Research Center ImmunoSciences (RCIS) at the Charité Berlin.
The unique data sets, the clinically relevant and interesting research subject and the joint genetic, bioinformatic, and clinical expertise of the IIEG and the RCIS make this project an ideal opportunity to qualify in modern human genetics

The institutes:
The IIEG (http://www.iieg-luebeck.de) is among the top 5 cardiovascular research institutes in Germany and is located at the campus of the University of Lübeck, located on the coast of the Baltic Sea. It is anchored within the Excellence Cluster Inflammation at Interfaces (www.inflammation-at-interfaces.de) and engaged in large networks of national and international collaborations (i.e.CARDIoGRAM). The IIEG aims to identify and characterize the genetic risk factors that predispose to heart attack. English is a common language in the group.
The RCIS (http://rcis.charite.de/en) is an interdisciplinary and application oriented network of researchers in the field of immunology at the Charité Berlin. It cooperates, interacts and exchanges expertise between junior scientists, established scientists and clinicians. The PhD student will be deputed from the RCIS to the IIEG and will defend the thesis at the Charité Berlin. It is possible to return to the Charité in the course of the project.
 
Pay level: TV-L E13/BAT IIa/2

Start: January 2015 or earlier
 

Contact detail


How to apply:
Please send your full application documents (pdf-files) per email to:
jeanette.erdmann@iieg.uni-luebeck.de
a.schaefer@ikmb.uni-kiel.de
Send application to
For more detailed information please inquire directly at
Prof. Dr. Jeanette Erdmann,
email: jeanette.erdmann@iieg.uni-luebeck.de
phone: +49 (0)451 - 500 4857

or

Dr. Arne Schäfer,
phone: +49 (0)30 - 450 562 322
e-mail: a.schaefer@ikmb.uni-kiel.de.
 

Job profile


Working hours
Full-Time
Contract duration
Temporary
Type of job
PhD Project
Work experience
job experience is not required
Region
Germany (Berlin, Schleswig-Holstein)
Working place
23562 Lübeck
Area of expertise
Biology & Life Sciences, Human medicine
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