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Genetic And Functional Genomic Analysis Of Tumor Progression And Therapy Response

The Institute of Neuropathology at the Justus Liebig University in Giessen, Germany, Director Prof. Till Acker, is inviting applications for a
 
Postdoc position:
Genetic And Functional Genomic Analysis Of Tumor Progression And Therapy Response

 
The position is available immediately.
 
Your profile
We are looking for enthusiastic and highly motivated applicants holding, or about to obtain, a PhD degree. The applicants should possess a strong research background in molecular and cell biology, experience with next generation sequencing and data analysis is highly desirable. Of additional advantage will be prior experience in one or more of the following areas: cancer research, in vivo tumor models, functional genomics or other high-throughput screening methods, hypoxic signalling, receptor tyrosine kinase (RTK) signalling.
 
Topic
Our group has a long-standing interest in the mechanisms of brain tumor growth and progression. In particular, we have focused on the role of microenvironmental factors, particularly hypoxia, hypoxia inducible factors (HIFs) and oxygen sensors of the PHD family, in the regulation of tumor progression and key hallmarks of cancer including angiogenesis, invasion, metastasis, metabolism, differentiation and therapy response. Our main research interest is to understand the role of microenvironmental sensors and their downstream targets in tumor progression and assess their potential for therapeutic application.
The proposed project will aim to:
1) Develop a panel of genetic markers for improved, personalized brain tumor diagnosis and treatment
2) Elucidate novel therapeutic targets directed at the key microenvironmental sensor PHD3 in brain tumor growth and signalling.
 
What we offer
Our international team offers an open, supportive, dynamic and motivating academic environment with excellent training opportunities. We have won a number of external research grants and are involved in several national and international collaborative projects. We use a wide spectrum of methods: cloning, cell culture, biochemistry, qRT-PCR, FACS, ELISA, cell-based assays (proliferation, apoptosis, migration, 3D invasion, stem cell isolation and cultivation etc.), shRNA/siRNA screens, proteomics, transactivation assays, virally-based gene delivery and RNAi or CRISPR/Cas9-mediated silencing, immunohistochemistry, in situ hybridization, light, epifluorescence and confocal microscopy, image analysis, animal models and in vivo tumor models.
 
Application
Please send your applications, including a CV, certificates and references to Dr. Boyan Garvalov
Email: Boyan.Garvalov at patho.med.uni-giessen.de;
Please cite reference ID “Jobvector Postdoc 2015-03”.
 
Website
http://www.ukgm.de/ugm_2/deu/ugi_npa/5424.html
 
Selected references
Henze et al, Nature Commun 2014, 5:5582
Garvalov et al, Nature Commun 2014, 5:5577
Filatova et al, Biochim Biophys Acta 2013, 1830(2):2496-508
Sawamiphak et al, Nature 2010; 465(7297):487-91
Henze et al, Cancer Research 2010;70(1):357-66
Seidel et al, Brain 2010;133(4):983-95
Acker et al, Cancer Cell 2005; 8(2):131-41
Compernolle et al, Nature Medicine 2002; 8(7):702-10
 

Contact detail


How to apply:
Please send your applications, including a CV, certificates and references to Dr. Boyan Garvalov
Email: Boyan.Garvalov at patho.med.uni-giessen.de;
Please cite reference ID “Jobvector Postdoc 2015-03”.
 
Send application to
Boyan.Garvalov at patho.med.uni-giessen.de

Job profile


Working hours
Full-Time
Contract duration
Temporary
Type of job
Postdoc
Work experience
job experience is not required
Region
Germany (Hessen)
Working place
35392 Giessen
Area of expertise
Biology & Life Sciences
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