A PhD position in genetic predisposition to osteoporosis

A PhD position
is available from February 1st 2017
in the Department of Clinical Pharmacology
at the University of Göttingen.
The Project
Osteoporosis is a major disease burden in elderly. More than 15% of the people above 50 years of age suffer from osteoporosis. These individuals have an increased risk of fractures, which in higher age not only substantially reduce quality of life, but may be life threatening. In this project we are analyzing inborne genetic variants as risk factors for developing osteoporosis. We are especially interested in genetic variants in the 11β-HSD1 gene, which controls the synthesis of cortisol in bone.   
Important parts of this project will be to perform:
  • Genetic analyses in patients with osteoporosis
  • Detailed functional characterization of the effects of the identified variants. These will include reporter gene assays, mobility shift assays, chromatin immunoprecipitation and real-time gene expression analyses.
  • Detailed characterization of the role of 11β-HSD1 in bone cell development using CRISPR/Cas9 based knock out in model cells and human mesenchymal stem cells 
We are looking for a highly motivated candidate with a master’s degree (or equivalent) in molecular biology, biochemistry, or molecular medicine. Experience with cell culture, recombinant DNA technologies, or analysis of transcriptional regulation will be an advantage.
We offer a TV-L 13 (50%) position for three years, an opportunity to work in a well-equipped molecular and cell biology laboratory, and professional supervision. The project is a collaboration between the groups of Mladen Tzvetkov (PhD) and Heide Siggelkow (MD). Both groups combine a long-lasting experience in the fields of endocrinology, bone cell biology and functional genetic analyses. Project relevant papers of our groups are: Siggelkow et al. JCEM 2014 (PMID: 24285685) and O’Brien et al. JPET (PMID: 23922447).
Applications should be addressed by December 31st 2016 to Dr. Mladen Tzvetkov: University Medical Center Göttingen, Institute of Clinical Pharmacology, email: mtzvetk@gwdg.de.
The University of Göttingen is an equal opportunity employer and places particular emphasis on fostering career opportunities for women. Qualified women are therefore strongly encouraged to apply. Applicants with disabilities and equal qualifications will be given preferential treatment.
How to apply:
Send application to
Dr. Mladen Tzvetkov
University Medical Center Göttingen
Institute of Clinical Pharmacology
email: mtzvetk@gwdg.de
While applying for the job please refer to jobvector and use the following reference number: TZ 74/4-1

About Universitätsmedizin Göttingen

The University Medical Center Göttingen is a tertiary care center and offers great development potential. Its 7000 employees work in over 60 departments and facilities to provide top-quality patient care, excellent research and modern teaching. Göttingen, “City of Science”, lies near the center of Germany and is home to northern Germany’s only University...

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