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A PhD position in genetic predisposition to osteoporosis

A PhD position
is available from February 1st 2017
in the Department of Clinical Pharmacology
at the University of Göttingen.
 
 
The Project
Osteoporosis is a major disease burden in elderly. More than 15% of the people above 50 years of age suffer from osteoporosis. These individuals have an increased risk of fractures, which in higher age not only substantially reduce quality of life, but may be life threatening. In this project we are analyzing inborne genetic variants as risk factors for developing osteoporosis. We are especially interested in genetic variants in the 11β-HSD1 gene, which controls the synthesis of cortisol in bone.   
 
Important parts of this project will be to perform:
  • Genetic analyses in patients with osteoporosis
  • Detailed functional characterization of the effects of the identified variants. These will include reporter gene assays, mobility shift assays, chromatin immunoprecipitation and real-time gene expression analyses.
  • Detailed characterization of the role of 11β-HSD1 in bone cell development using CRISPR/Cas9 based knock out in model cells and human mesenchymal stem cells 
 
We are looking for a highly motivated candidate with a master’s degree (or equivalent) in molecular biology, biochemistry, or molecular medicine. Experience with cell culture, recombinant DNA technologies, or analysis of transcriptional regulation will be an advantage.
 
We offer a TV-L 13 (50%) position for three years, an opportunity to work in a well-equipped molecular and cell biology laboratory, and professional supervision. The project is a collaboration between the groups of Mladen Tzvetkov (PhD) and Heide Siggelkow (MD). Both groups combine a long-lasting experience in the fields of endocrinology, bone cell biology and functional genetic analyses. Project relevant papers of our groups are: Siggelkow et al. JCEM 2014 (PMID: 24285685) and O’Brien et al. JPET (PMID: 23922447).
 
Applications should be addressed by December 31st 2016 to Dr. Mladen Tzvetkov: University Medical Center Göttingen, Institute of Clinical Pharmacology, email: mtzvetk@gwdg.de.
 
The University of Göttingen is an equal opportunity employer and places particular emphasis on fostering career opportunities for women. Qualified women are therefore strongly encouraged to apply. Applicants with disabilities and equal qualifications will be given preferential treatment.
 

Contact detail


How to apply:
E-mail
Send application to
Dr. Mladen Tzvetkov
University Medical Center Göttingen
Institute of Clinical Pharmacology
email: mtzvetk@gwdg.de

Job profile


Working hours
Part-Time
Contract duration
Temporary
Type of job
PhD Project
Work experience
job experience is not required
Region
Germany (Niedersachsen)
Working place
37075 Göttingen
Area of expertise
Biology & Life Sciences, Pharmaceutics
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