Adhesive mechansims of Salmonella enterica

October, 2016
 
The Division of Microbiology at the University Osnabrück opens a position on:
 
Adhesive mechanisms of Salmonella enterica
 
Applications on are invited for a PhD project investigating the interaction of Salmonella enterica with mammalian host cells with focus on adhesion to polarized epithelial cells. A position for a postgraduate scientist (pay scale E13, 50-65 %) is immediately available for an initial period of 2 years. An extension is anticipated.
 
Our group is interested in understanding the molecular and cellular basis of bacterial pathogenesis. Of particular interest are the virulence functions of Salmonella enterica required for the adhesion to, and invasion of polarized cells. We investigate the structure-function relationship of the giant non-fimbrial adhesin SiiE of S. enterica , the cognate type I secretion system for SiiE, and the mechanisms of controlled secretion and surface retention of SiiE. Our analyses utilize techniques of advanced bacterial genetics, infection models with polarized cells, ultrastructural analyses, and protein structure analyses.
Candidates should have sound working experience with standard and advanced microscopy techniques and a strong background in microbiology will be of advantage.
 
The Division of Microbiology operates several light microscopy systems providing wide-field, CLSM, spinning disk, TIRF, FRAP techniques with live cell environment, and micromanipulation under S2/BL2 conditions. Further microscopy techniques such as F-PALM, TEM and AFM are locally available within the framework of DFG collaborative research center SFB 944, institutional infrastructure and intramural collaborations.
 
The University Osnabrück offers structured study programs for postgraduate candidates, such as the integrated graduate school of SFB 944 ‘Physiology and dynamics of cellular microcompartments’.
 
How to apply:
Applications should include CV, academic degrees, description of previous research projects, and addresses of at least two referees. Applications and inquiries should be submitted by E-mail to:
Send application to
Prof. Dr. Michael Hensel
Universität Osnabrück, Abt. Mikrobiologie
Fachbereich Biologie/Chemie
Barbarastraße 11
49076 Osnabrück
Germany
E-Mail: Michael.Hensel@biologie.uni-osnabrueck.de
 
While applying for the job please refer to jobvector and use the following reference number: MB1610A

About Universität Osnabrück

Den Bildungsanforderungen der Zeit entsprechen Internationale Erfolge in der Forschung, ein vielfältiges modernes Studienangebot und zahlreiche Reformen, insbesondere in der Lehre, prägen Gesicht und Geschichte der Universität Osnabrück. Als junge Universität stellt sie sich reformorientiert den veränderten Bildungsanforderungen ihrer Zeit. Erfolgreiche...

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