Analysis of lipid rafts in fungal model organisms

At the Leibniz ScienceCampus InfectoOptics in Jena infection biologists and photonics scientists work together to develop urgently needed novel optical diagnostic tools for infectious diseases. InfectoOptics combines research in the field of optical high technologies with current topics in infection biology. The InfectoOptics doctoral researchers are integrated into the Jena School for Microbial Communication (, a graduate training program funded by the Excellence Initiative of the German Research Foundation.
The Leibniz ScienceCampus InfectoOptics now invites applications for a
Doctoral Researcher Position TV-L E13 50% (Ref.No. 13/2015)
to conduct research on the project

Analysis of lipid rafts in fungal model organisms
With this project, the analysis of lipid rafts in the model basidiomycete Schizophyllum commune and the human pathogen Aspergillus fumigatus is combined. For A. fumigatus, a genome-wide knock-out library is being constructed in the working group of Prof. Brakhage which will be available to test potential components of lipid rafts. For the visualization, lipid raft enhanced concentrations of G-protein coupled receptors, flotilllin, but also ergosterol are measured. Since cell wall elongation in growing hyphal tips is a natural place for easy access of signals, a higher signal perception is expected at the hyphal tip. After showing this signaling hotspot in A. fumigatus, this can be verified using the isotropic growth of yeast with C. albicans. The comparison of hyphal versus yeast growth allows a direct correlation of gene functions to filamentous growth by molecular biology and genetic analysis. In addition to fluorescence-in vivo-video microscopy under high resolution conditions, Raman spectrometry and AFM will be used to reveal functional association of lipid rafts with specific signal perception functions and polar hyphal growth.
More projects details:

We expect:
  • a Master’s degree (or equivalent) in Microbiology, Biology or Biogeosciences. Candidates about to earn their degree are welcome to apply.
  • desirable methodological skills: working with fungi, molecular biology, genetics.
  • high motivation and interest to join one of the interdisciplinary research areas of InfectoOptics
  • creativity and interest to shape your own thesis project
  • an integrative and cooperative personality with enthusiasm for actively participating in the Leibniz ScienceCampus Community
  • very good communication skills in English
We offer:
  • a highly communicative atmosphere within a scientific network providing top-level research facilities
  • a doctoral researcher position (TV-L E13, 50%) funded for three years as well as generous basic research funding
  • a comprehensive mentoring program with supervision by a team of advisors
  • Membership at the Excellence Graduate School ‘Jena School for Microbial Communication’ (JSMC), currently encompassing around 150 dedicated doctoral researchers and providing a top-level PhD training program with courses in state-of-the-art research technologies and soft skills
  • Jena – City of Science: a young and lively town with dynamic business activities, successful scientific centers of innovation and a vibrant cultural scene around the famous Friedrich Schiller University
Friedrich Schiller University and HKI are equal opportunity employers. We also welcome applications from disabled persons.

How to apply:
The application procedure takes place exclusively online via the JSMC website:
Please acquaint yourself with the open PhD projects and the application process described on this website. Selected applicants will be invited to attend a recruitment meeting in Jena (January 2016). Awarding decisions will be made shortly thereafter, allowing the projects to start immediately.

Application deadline: November 17, 2015
Send application to
Katja Präfcke
Neugasse 23
07743 Jena

While applying for the job please refer to jobvector and use the following reference number: Ref.No. 13/2015

About Jena School for Microbial Communication

The Jena School for Microbial Communication (JSMC) is funded by the German Excellence Initiative . It conceptionally combines different research areas (microbial communities, interactions with plant, animal and human hosts and environmental interactions) to a comprehensive picture of microbial communication ( JSMC is an ambitious Graduate School currently hosting over...

More about Jena School for Microbial Communication

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