Analysis of the role of the p53-inducible 14-3-3sigma in epidermal and intestinal tumor suppression in mouse models

We are looking for a highly motivated PhD student to join our team at the Ludwig-Maximilians-University in Munich. We are interested in understanding the role of p53 regulated in the suppression of intestinal and skin cancer. p53 is the most commonly mutated tumor suppressor gene and encodes a transcription factor that activates target genes, which mediate the effects of p53. In the past we have identified and characterized several p53 target genes, such as 14-3-3sigma and miR-34a. Currently, we are studying there in vivo relevance and function using conditional deletions of these genes in epidermal and intestinal tumor models. The 14-3-3sigma gene was described by us as a p53 induced cell cycle regulator (Hermeking et al. (1997) Molecular Cell 1, p. 3-11). Subsequently we determined the structure and comprehensively identified 14-3-3sigma interacting proteins. More recently we developed a conditional 14-3-3sigma knock-out mouse (Winter et al. (2016) Oncotarget 7(30): 46862-70). However, the relevance of 14-3-3sigma for tumor suppression and the in vivo function of 14-3-3sigma have remained largely unclear. The project offered here aims to solve these questions. Suitable candidates should have a background in the analysis of transgenic mice and a strong interest in cancer biology. We offer a highly innovative research environment and the possibility to validate basic research results in clinical samples. The final degree obtained will either be a Dr. rer. nat. or a PhD, depending on the program selection.
For more information on the group and links to publications see:
How to apply:
Send application to
Prof. Heiko Hermeking
Experimental and Molecular Pathology
Institute of Pathology
Ludwig-Maximilians-Universität München
Thalkirchner Str. 36
D-80337 Munich, Germany
Tel.: ++ 49-89-2180-73685
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About Ludwig-Maximilians-Universität München

The LMU and its Medical Faculty have established services and programs for young investigators. The Graduate Center of the LMU is a central support unit for doctoral students and coordinates the Academic Career Program, the Doctoral Research Program, and the Doctoral Exchange Program. The Medical Faculty participates in the structural doctoral programs of six Graduate Schools, two of which...

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