Doctoral research fellow to study the signaling mechanism, subcellular localization and regulation of guanylyl cyclase A, the receptor for atrial natriuretic peptide

The Institute of Physiology at the University of Würzburg invites applications for a

Doctoral research fellow (E13, 65%)
to study the signaling mechanism, subcellular localization and regulation of guanylyl cyclase A, the receptor for atrial natriuretic peptide
 
We are seeking highly motivated candidates in the field of signal transduction particularly focusing on novel aspects of cyclic GMP-mediated signaling by membrane guanylyl cyclases. Applicants will have a completed degree in biology, physics, biochemistry or a related field in natural sciences, good knowledge of basic molecular biology and/or protein chemistry, and enthusiastic interest in molecular cardiovascular research.
 
The overall goal of the project is to visualize the dynamics of ligand-induced conformational changes and internalization of GC-A, as representative member of the family of particulate guanylyl cyclase receptor. The multidisciplinary approach will utilize a variety of methods including molecular biology, biochemistry, high-end microscopy and FRET/FIAsH techniques in relevant cell culture systems. Please find some short overviews from M. Kuhn in: Nature. 2015;519:416; Circ Res. 2015;116:1278; EMBO J. 2015;34:270).
 
The project is part of a network of scientists in Würzburg and Jena (Transregio 166), linking their expertise and infrastructure for the application of high-end fluorescence microscopy to elucidate membrane receptor function (see http://jobs.zeit.de/jobs/jena_wuerzburg_postdoc-stellen_sonderforschungsbereich_high-end_light_microscopy_elucidates_membrane_receptor_funct_115152.html; http://gepris.dfg.de/gepris/projekt/258780946). The Institute of Physiology is part of this network and offers excellent laboratory space and modern techniques which allow to answer scientific questions in an interdisciplinary way.
 
Applicants please send CV and contact coordinates of 1-2 references (as a single PDF file) by the end of February 2016 to Dr. Michaela Kuhn, Physiologisches Institut I, Universität Würzburg, Röntgenring 9, D-97070 Würzburg, Germany. Tel: (00)49 931 31 82721, E-mail: sekretariat-kuhn@mail.uni-wuerzburg.de
 
How to apply:
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Send application to
Dr. Michaela Kuhn, Physiologisches Institut I, Universität Würzburg, Röntgenring 9, D-97070 Würzburg, Germany. Tel: (00)49 931 31 82721, E-mail: sekretariat-kuhn@mail.uni-wuerzburg.de
 
While applying for the job please refer to jobvector and use the following reference number: 220116

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