Phd position in Biology / Biochemistry / Molecular Medicine
(Biology, Biochemistry, Molecular Medicine)
for a project focused on redox-dependent mechanisms of vascular homeostasis.
NADPH oxidases are enzymes solely dedicated to produce reactive oxygen species which play an important role as signaling molecules under physiological and pathological conditions. Of the 7 isoforms described, Nox4 stands a part as the only enzyme constitutively active with essential contribution to cellular homeostasis and protective function in the vasculature under stress condition.
Our group aims to further identify physiological functions of this enzyme in the vasculature with the aid of knockout mice in disease models like diabetes, hypertension, and atherosclerosis. To dissect the specific underlying mechanisms we use cuting edge technologies like LC/MS/MS for metabolic analysis, gene expression profiling (arrays and RNA Seq) coupled to classical techniques in cell biology and protein chemistry.
We seek for highly motivated candidates, with great passion for science and ambition to develop a successful career. Candidates should be able to work independently in a fast developing environment with great ability to integrate complex data sets.
We offer top quality research in a very productive and internationally recognized team. Our institute is a member of diverse grant initiatives with wide collaborative network.
Candidates should send CV and motivation letter to email@example.com
While applying for the job please refer to jobvector and use the following reference number: JoVe05-03/2016
Vascular Research Centre
Theodor-Stern Kai 7
Tel: 069 6301 6049, Internet: www.vrc.uni-frankfurt.de, Email: firstname.lastname@example.org
About Goethe-Universität Frankfurt am Main
Das Vascular Research Centers Frankfurt ( www.vrc.uni-frankfurt.de) ist Mitglied im Excellenzcluster Kardio-Pulmonales System der Excellenzinitiative des Bundes ( www.eccps.de ) und im Nationalen Gesundheitszentrum für Herz-Kreislaufforschung. Direkte DFG-Förderung erfolgt im Rahmen des SFB 815 "Redox-Regulation: Generatorsysteme und Funktionelle Konsequenzen" (...More about Goethe-Universität Frankfurt am Main