PhD position stress-induced epigenetic changes in the brain

 TU Darmstadt  Darmstadt
The Biology Department of the TU Darmstadt (Darmstadt University of Technology), Germany, invites applications for a
PhD position (salary grade 65% E13 TV-TU Darmstadt) in the Stem Cell and Developmental Biology group. The appointment is for three years.
This is an exciting opportunity to perform research on stress-induced epigenetic changes in the brain. Stressful events can lead to long-lasting disease-relevant changes in brain function (e.g. cognitive impairment, posttraumatic stress disorder) and the epigenetic modulation of gene expression plays a crucial role in the brain’s response to stress. Proteins that bind to methylated DNA and influence chromatin structure and gene expression represent critical molecular links between epigenetic marks and neuronal function. MECP2 acts as such an epigenetic reader and plays an essential role in the regulation of a stress hormone system in the brain.
We are looking for a highly motivated person who is interested in performing research in the field of epigenetic gene expression regulation and molecular neurobiology in a dynamic and young international team.
This project involves a large spectrum of modern methodologies including RNA-seq, ChIP-seq, CRISPR/Cas-mediated genome editing and sophisticated primary cell culture work.
Job description
The successful candidate should conduct research projects on stress-induced epigenetic changes in the brain leading to a PhD degree.
Required qualifications and experience
A Master degree in a relevant field (e.g. biology, molecular medicine, biochemistry).
Very good molecular methods skills.
Bioinformatics expertise (gene expression analyses, programming skills) is desirable but not obligatory.
Experience with mice/isolation of primary cells is of advantage.
Strong ambition to develop into an independent scientist.
Excellent problem-solving skills.
Excellent communication, organizational and interpersonal skills.
The TU Darmstadt is a family-friendly university, intends to increase the number of female faculty members and particularly encourages female candidates to apply. In case of equal qualifications applicants with a degree of disability of at least 50 or equal will be given preference. Wages and salaries are according to the collective agreements on salary scales, which apply to the TU Darmstadt (TV-TU Darmstadt). Highly motivated, enthusiastic ad ambitious candidates are invited to send an application including CV, certificates, and names of reference persons to Ulrike Nuber (nuber[at]
Application deadline: February 28, 2017
How to apply:
Please send an application including CV, certificates, and names of reference persons to Ulrike Nuber (nuber[at]
Send application to
Prof. Dr. Ulrike Nuber
Stem Cell and Developmental Biology
TU Darmstadt
Schnittspahnstrasse 13
64287 Darmstadt
While applying for the job please refer to jobvector and use the following reference number: 2017-a

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