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PhD (SFB1243-A14): Evolution of gene expression in blood cancer

The Challenge
While the evolutionary nature of cancer is well established, it is challenging to generate and analyze data to quantify the dynamics of this Darwinian process. This is a clinical problem, for example when therapy-resistant cancer cells regrow after an initially successful treatment. Hence, patients die because the tumor is able to evolve. Hematologic neoplasms such as leukemia and lymphoma are well suited to study this process, because intact cells can be sampled and studied in detail over the course of the disease. Within this project, gene expression evolution of acute myeloid leukaemia (AML) in patients and patient-derived xenograft mouse models in the presence and absence of therapeutic selection pressure will be investigated. This will be done with our established single-cell RNA-seq technologies (Fluidigm, SCRB-seq, Drop-seq)
For further information please see www.sfb1243.bio.lmu.de and Enard lab.
 
Your Responsibilities
  • Generate bulk and single-cell RNA-seq data from evolving AML samples
  • Analyse patterns of gene expression evolution with respect to clonal composition and selection pressures and quantify directional versus neutral expression evolution..
 
Your Opportunities
  • We offer a highly interdisciplinary environment for state-of-the-art genomic technologies and computational and evolutionary data analysis within the group and within the Collaborative Research Centre (SFB) 1243.
  • You will be part of the Integrated Research Training Group (IRTG), a structured graduate program committed to providing an excellent all-round graduate education.
 
Your profile
  • Candidates should hold a diploma or a master’s degree in biology, molecular biomedicine, biotechnology, or a related subject.
  • You are highly motivated, team-oriented graduate, capable of independent working with a strong background in molecular biology.
  • Experience in scripting, statistical analyses and/or genomic analyses is advantageous.
 
Online applications are now being accepted until February 21, 2016. Please apply solely via http://portal.graduatecenter-lmu.de/ocgc/sfb1243
The position should start as soon as possible and is for a period of 3-4 years. The LMU is an equal opportunity employer. Preference will be given to suitably qualified female applicants or handicapped people, all other considerations being equal.

Contact detail


How to apply:
http://portal.graduatecenter-lmu.de/ocgc/sfb1243
Send application to
Prof. Dr. Wolfgang Enard Anthropology and Human Genomics, Chair Department Biology II Ludwig Maximilians University Munich Grosshaderner Str. 2 D-82152 Martinsried E-mail: enard@bio.lmu.de

Job profile


Working hours
Full-Time
Contract duration
Temporary
Type of job
PhD Project
Work experience
job experience is not required
Region
Germany (Bayern)
Working place
82152 Planegg - Martinsried
Area of expertise
Biology & Life Sciences, Human medicine