This project is carried out together with the Physiological Institute (University Giessen, Prof. Susanne Rohrbach) and investigates the role of the ubiquitin E3 ligase SIAH2 to the development of cor pulmonale. We have found that mice lacking the ubiquitin E3 ligase SIAH2 are largely protected mice from hypoxia-induced cor pulmonale. It will now be investigated whether heart-specific deletion of Siah2 protects against right ventricular hypertrophy (RVH). We will also assess whether ongoing RVH can be inhibited or even reversed by inducible ablation of Siah2. The molecular targets, signaling pathways and metabolic changes regulated by SIAH2 in the right ventricle will be identified and further characterized. Additionally, we will test the applicability of SIAH2 inhibitors for the prevention and treatment of RVH.
This project is funded by the CRC1213 and employs a battery of diffent methods from biochemistry/molecular biology and also uses mouse models (https://www.uni-giessen.de/forschung/einrichtungen/sfb/corpulmonale). Your profile: You have succesfully finished your Master or equivalent degree. You are highly self-motivated, ambitious and can work well in a highly active international research team, but also work on your own. The position is funded until June 2020 gefördert, a prolongation is potentially possible. The university is an equal opportunity employer, and applications from women or candidates with children are encouraged. Applications of severely disabled with same suitability are preferred. Application deadline is end of October 2016.
While applying for the job please refer to jobvector and use the following reference number: SFB 1213
35392 Giessen (Germany)
About Justus-Liebig-Universität Gießen
Our group in the Biochemical Institute of the Justus-Liebig-University in Giessen investigates the mechanisms of signal transduction and inducible gene expression in eukaryotic cells using the transcription factors NF-kB and p53 as model systems. These transcription factors are important regulators of the immune response and cell proliferation and are thus found to be dysregulated in a...More about Justus-Liebig-Universität Gießen