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PhD student - Cellular Microbiology - in the field of pathogen-host interaction

Open position for a

PhD student
Cellular Microbiology


“Regulation and activity of HtrA proteases in the Helicobacter pylori-driven carcinogenesis”

We are seeking a highly motivated and talented PhD student in the field of pathogen-host interaction. Helicobacter pylori is a bacterial class-I carcinogen that can induce chronic gastritis, ulceration, MALT lymphoma and gastric cancer. In particular, we are interested in the molecular mechanisms how H. pylori interferes with host cell functions. In our previous work, we identified a crucially important role for the bacterial serine protease HtrA of H. pylori. HtrA directly cleaves the cell adhesion and tumor suppressor E-cadherin on gastric epithelial host cells. The announced project will continue our efforts in this field. We offer a comprehensive training in cell biology and molecular biology in the field of pathogen-host interactions. We are well connected in an international network and parts of the training can be done in one of our partner laboratories (optionally).

The project will focus on two aspects of HtrA biology:
i. Biochemical analysis of HtrA regulation and activity
ii. Functional consequences of HtrA-E-cadherin interaction on intracellular signal transduction

Recent publications:
Hoy, 2010, EMBO Rep, 11:798-804
Schmidt, 2016, Sci Rep, 6: 23264
Schmidt, 2016, Gut Pathog, 8:29

Candidates:
  • should have a strong background in cell biology, and experience either in infection biology, or in biochemistry.
  • are willing to work on a highly competitive research field
  • have excellent communication and interpersonal skills
  • will collaborate with internal and external partners and support other group members
  • will employ cutting-edge technologies and standard biochemical, molecular biology tools in combination with infection biology to study protease functions during pathogen-host interaction
We hold a state-of-the art laboratory at the Paris-Lodron University of Salzburg in Austria, a beautiful place at the northern boundary of the Alps. The Department of Molecular Biology provides broad possibilities for interaction and support. Our group is a member of the international "PhD program ICA" (University of Salzburg/FWF), the DSP PLUS, and a member of the priority program "Bioscience and Health" (University of Salzburg).

Please send your complete application together with the CV (refer to GZ A 0116/1-2016) to Serviceeinrichtung Personal, Kapitelgasse 4, 5020 Salzburg, Österreich by December 28, 2016. For more information please contact Silja Wessler (silja.wessler@sbg.ac.at), phone: + 43 (0) 662 8044 7210.

Contact detail


How to apply:
Please send your complete application together with the CV (refer to GZ A 0116/1-2016) to Serviceeinrichtung Personal, Kapitelgasse 4, 5020 Salzburg, Österreich by December 28, 2016.
Send application to
For more information please contact Silja Wessler (silja.wessler@sbg.ac.at), phone: + 43 (0) 662 8044 7210.

Job profile


Working hours
Full-Time
Contract duration
Temporary
Type of job
PhD Project
Work experience
job experience is not required
Region
Austria (Salzburg)
Working place
5020 Salzburg
Area of expertise
Biology & Life Sciences
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