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Postdoc in Bioinformatics / Computational Biology

Workscope: Research Associate

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The Department of Pediatric Hematology, Oncology and Clinical Immunology (Head: Prof. Dr. Borkhardt) at the Center for Child and Adolescent Health (Heinrich Heine University Duesseldorf / Germany) is looking for a highly motivated
 
Postdoc in Bioinformatics / Computational Biology
 
The position is immediately available with an initial appointment for one year with the possibility of an extension.
 
Description
We, the Department of Pediatric Hematology, Oncology and Clinical Immunology (Head: Prof. Dr. Borkhardt) at Heinrich Heine University Duesseldorf / Germany performs integrative data analysis of complex sequencing-derived datasets.
Our group is interested in the identification and functional characterization of miRNAs and other ncRNAs and their interplay with coding genes in aggressive non-Hodgkin lymphoma and leukemia. We are part of the International Cancer Genome Consortium ICGC MMML-Seq. Consortia like these generate large omics datasets (whole genome, transcriptome, miRNAome, methylome) for hundreds of patient samples. The analysis of these datasets has uncovered the mutational landscape and pathogenetic mechanisms of the respective tumor types.
In addition, our department hosts a sequencing core facility and participates in further sequencing studies on cancer research. We support other groups in the preparation, execution and analysis of large-scale sequencing data.
We are seeking a postdoctoral fellow to perform integrative analysis on large genomic and epigenomic (including RNA-seq and miRNA-seq) datasets, which are either already available in our group or which will be generated using state-of-the-art techniques. This also includes uncommon data such as PAR-CLIP for the identification of RNA binding sites of RNA-binding proteins. The integrative analysis of multiple of these datasets allows a deeper and more complex understanding of the interplay of genomic and epigenomic mechanisms in tumor biology.
 
Your profile:
  • PhD in bioinformatics, computational biology, or computer science (or equivalent experience)
  • Excellent oral and written communication skills in English
  • Knowledge of German is not a prerequisite but an advantage
  • Good understanding of molecular and cancer biology
  • Experience in the analysis of next generation sequencing data (at least any two of the following: DNA-Seq, RNA-Seq, Chip-Seq, CLIP-Seq)
  • Use existing as well as develop new methods and tools for handling, analyzing and interpreting sequencing data
  • Working experience with UNIX-like operating systems including HPC environments 
  • Programming skills with scripting languages such as Perl, Python or Bash scripting
  • Solid knowledge in statistics and R programming
  • Experience with bayesian models and/or network modeling is a plus
  • Ability to work independently while collaborating and assisting the team in its common research goals
 
We offer:
  • Highly interesting position in an interdisciplinary setting
  • Participation in leading national and international research consortia
  • Stimulating research environment
  • Training options (iGRAD)
  • Attractive surroundings; Düsseldorf is an attractive city with the media harbour and the old town. Given its large university, it has a lively student as well as cultural scene (Deutsche Oper am Rhein, Kommödchen, several festivals over the year, Fortuna Düsseldorf). Düsseldorf is based at the heart of the lively Rhein-Ruhr metropolitan region, the largest metropolitan region in Germany with over 11 million inhabitants.
Salaries will be based on TV-L guidelines (TV-L E13). Part-time work is theoretically also an option.
 
 
The contract will be concluded with Heinrich Heine University Düsseldorf.
Female candidates are encouraged to apply; they will be given preference in cases of equal aptitude, ability, and professional achievements unless there are exceptional reasons for choosing another applicant.
 
Applications from suitably qualified severely disabled persons or disabled persons regarded as being of equal status according to Book IX of the German Social Legal Code (SGB – Soziales Gesetzbuch) are encouraged. Disabled applicants will be given preferential consideration in the case of equal aptitude.
 
For administrative reasons, we cannot return applications. In submitting your application, you give your consent to the remaining of the application documents at the university hospital Düsseldorf. 
 
For questions regarding the position, please contact jessica.hoell@med.uni-duesseldorf.de.

Contact detail


How to apply:
Please submit your application within four weeks of the appearance of this offer containing a letter of motivation, CV, description of scientific experience and the addresses of two referees via email or to

Universitätsklinikum Düsseldorf
 
D 01.2.1 – Kennziffer: 148E/16, Moorenstr. 5, 40225 Düsseldorf
Send application to
Dr. Jessica Höll
Klinik für Kinderonkologie
Moorenstraße 5
40225 Düsseldorf
Germany
jessica.hoell@med.uni-duesseldorf.de

Job profile


Working hours
Full-Time
Contract duration
Temporary
Type of job
Postdoc
Work experience
jobexperience is required
Region
Germany (Nordrhein-Westfalen)
Working place
40225 Düsseldorf
Area of expertise
Biology & Life Sciences
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