Postdoc, Ralser Lab, The Francis Crick Institute

Postdoctoral Training Fellow in Data-driven (Computational) Biology. This is a full-time fixed term position for 4 years on Crick Terms & Conditions of Employment Salary between £33,500 - £36,600 per annum, subject to skills & experience

We seek a talented and motivated postdoc in Data-driven computational biology to join Markus Ralser’s laboratory, ‘Dynamics and evolution of metabolic networks’, at the Francis Crick Institute.

PROJECT SUMMARY Dr Ralser’s laboratory focuses to understand how cellular metabolism, the network of biochemical reactions in the cell, is regulated, how it evolved, and how it maintains functional integrity in the ever changing environment the cell is exposed to. This research addresses fundamental problems in the life sciences, where knowledge about cellular metabolic systems is required to develop new therapeutics and to understand the molecular basis of disease. Details of research projects currently being undertaken can be seen at: and

Research techniques used in the laboratory include functional genomics, mass spectrometry, and computational data analysis in the area of data driven biology. OBJECTIVES The research aims to understand how cells respond to changes in their immediate environment. Particular focus is set to dissect the reconfigurations occurring in cellular metabolism, under circumstances when cells prevent a collapse of their metabolic system upon a sudden change in the available nutrients. For this, time-resolved quantitative data, obtained by transcriptomics, mass spectrometry and nuclear magnetic resonance spectrometry will be analysed by methods of machine learning, and mapped to biological pathways.

In this project, some of the specific aims could include but not limited to:
● the analysis of biological datasets and networks ● the design of systematic, data-driven experiments
● to application of machine learning to detect patterns in biological systems

ABOUT US The Francis Crick institute is an entirely new institute with a distinctive vision of how biomedical research is conducted. It is one of the most significant projects in UK biomedical science for a generation. The institute’s labs have an international reputation for cutting edge research into basic biology and are committed to training the next generation of research scientists. On 1 April 2015, staff from the London Research Institute (CRUK) and National Institute for Medical Research (MRC) transferred to the Crick to form a fully functional research institute on four sites. In 2016, the Crick will move to a single new, purpose built research centre in St. Pancras which will house some 1,500 staff.

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About University of Cambridge

The Department of Biochemistry, Univ. of Cambridge Research into biological phenomena at the molecular level has provided much of the revolutionary science of the past twenty years. What Frederick Gowland Hopkins saw to be of growing importance in 1914, when he established the Department of Biochemistry in Cambridge, proved to be fertile ground for Nobel Laureates Fred Sanger, Rodney...

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