Respirasome dynamics and turnover in activated T lymphocytes

The Research Group „Cellular Proteomics“ (Head: Prof. Dr. Lothar Jänsch) within the Department Structure and Function of Proteins at the Helmholtz Centre for Infection Research in Braunschweig is looking for a
 
PhD candidate
 
for a project that is part of a joint graduate school PROCOMPASS with the Technical University of Braunschweig. The aim of the project “Respirasome dynamics and turnover in activated T lymphocytes” is the investigation of structure and dynamics of protein supercomplexes in the respiratory chain of mitochondria of human immune cells.
 
Project:
This PhD project intends to investigate the composition and dynamics of mitochondrial respirasomes from activated human T lymphocytes using an established proteomic workflow (UPLC-Orbitrap Fusion-MS quantitative peptide sequencing and PTM determination). Focus of the project will be the (i) dynamic reorganisation of respirasomes during activation of human T cells and (ii) the localisation of sites of production of reactive oxygens species (ROS). The workflow entails isolation and activation of human T cells, purification of mitochondria and protein complexes as well as determination of protein abundances and modifications.
 
 
Qualifications:
  • Master degree in Biology, Biotechnology or Biochemistry
  • Advanced knowledge and experience in working with proteins and mammalian cells
  • Strong interest in molecular immunology
  • Strong motivation, being a good team player, willing to work in an international group
  • Speaking and writing English fluently
 
With equal professional qualification, severely disabled persons will be prioritized.

 
Starting date: October 2016 (initial contract for 3 years)
 
Salary: TVöD E13 (65%)
Probation period: 6 months
 
Published: 27.07.2016
Closing date: 14.08.2016
 
Application:
Applicants are required to complete the online application form here: https://hzi.opencampus.net/
(Please refer to the job number 27/2016).
 
 
For further information, please contact Amanda Mühlmann (PA to Prof. Lothar Jänsch), tel: +49-531-6181-3001, e-mail: amanda.muehlmann@helmholtz-hzi.de.
 
https://www.helmholtz-hzi.de/en/research/research_topics/immune_response/cellular_proteom_research/

How to apply:
Applicants are required to complete the online application form here:
https://hzi.opencampus.net/
(Please refer to the job number 27/2016).
Send application to
For further information, please contact Amanda Mühlmann (PA to Prof. Lothar Jänsch), tel: +49-531-6181-3001, e-mail: amanda.muehlmann@helmholtz-hzi.de.
While applying for the job please refer to jobvector and use the following reference number: 27/2016

About Helmholtz-Zentrum für Infektionsforschung GmbH

Helmholtz-Zentrum für Infektionsforschung. Wir konzentrieren uns auf Bakterien, die medizinisch relevant sind oder als Modell für die Erforschung von Infektionsmechanismen genutzt werden. Mit unserer Arbeit leisten wir einen nachhaltigen Beitrag für die Gesundheitsvorsorge.

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