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1 PhD position (f/m) (Dr. rer. nat.) for graduates of life sciences and medicine with interest in basic and translational research

The University of Duisburg-Essen offers within the
DFG-funded Research Training Group 1739 (GRK1739)
1 PhD position (f/m)
(salary according TV-L E13 65%)
The GRK1739 “Molecular determinants of the cellular radiation response and their potential for response modulation” offers outstanding interdisciplinary scientific training and research opportunities for graduates of life sciences and medicine with interest in basic and translational research. Although DNA is the critical target for the lethal effects of ionizing radiation, there is increasing evidence that interactions with signals from the microenvironment, e.g., growth factors, nutrients, extracellular matrix proteins, and stromal cells crucially affect radiation sensitivity. In our research we aim to advance the dissection of the role of novel players in the cellular responses to ionizing radiation. These players include the membrane protein Caveolin 1 (Project of PD D. Klein). The project focuses on the interaction of Cav1 with DNA damage-induced signaling networks and cell-fate decisions. We will analyze differences in the impact of this molecule on the response of tumor and normal tissues to ionizing radiation, and explore the biological consequences of combining ionizing radiation with molecularly targeted drugs in clinically relevant in vitro and in vivo models. These studies will generate a molecular basis for the future therapeutic exploitation of tumor-microenvironment interactions to modulate the radiation response.
More details about the research training group can be found at: http://www.uni-due.de/med/forschung/grk1739/index.shtml
Applicants should hold a Master Degree or equivalent in e.g. Molecular Biology, Biochemistry, Biophysics, or Cell Biology. Candidates are selected on the basis of excellent performance in their studies and their motivation. The position will start in October 2016 and is funded for three years.
Please send the filled in application form (which can be found at: https://www.uni-due.de/med/forschung/grk1739/application-form.php) together with a cover letter, your CV and degree certificates as one pdf-file  as soon as possible the latest of 30th of August, 2016 to:
Coordination Research Training group 1739           
E-Mail: ivonne.schulte@uk-essen.de and
Incomplete applications or submissions only sent to the principal investigators cannot be considered. Interviews will be presumably held until 15th of September 16, 2016.

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Job profile

Working hours
Contract duration
Type of job
PhD Project
Work experience
job experience is not required
Germany (Nordrhein-Westfalen)
Working place
45239 Essen
Area of expertise
Biology & Life Sciences, Human medicine