Bioinformatics Scientist (f/m/d)

With more than 9.9 million registered potential stem cell donors globally, the DKMS family is the largest network of donor centres in the fight against blood cancer. Every day, 19 patients receive matching stem cells from DKMS donors – a new chance at life. DKMS Life Science Lab, located in Dresden, Germany, has become the world’s leading HLA genotyping lab, sequencing the HLA and KIR genes of more than 1 million samples at high-resolution each year. Our success builds on continuous research, aiming at taking advantage of the latest innovations in molecular biology and next generation sequencing and adapting those to the field of immunogenetics.

To continue our success story we are looking for a a skilled bioinformatician to become part of our Bioinformatics Team in Dresden as

Bioinformatics Scientist (f/m/d)

Since 2013 we perform genotyping of HLA markers using Illumina's NGS platforms in combination with in-house developed reagents and internally developed software for data analysis. Besides large-scale routine typing operations we have always been pioneering the application of novel technologies. We are engaged in actively exploring the potential of cutting edge NGS technologies (PacBio, Oxford Nanopore) for HLA typing. We continuously work on including further genetic markers (e.g., KIR, MIC) in our upfront donor typing profile, we characterize novel HLA alleles and collaborate on scientific projects that support our fight against blood cancer. The Bioinformatics team operates at the interface of algorithm development, developing analysis routines and workflow implementations for HLA, KIR, and bloodgroup genotyping. We are a team with diverse interests and experience in evolution, population genetics, developmental biology and next-generation sequencing (NGS) analyses. Rapidly growing data volumes and advancing technologies are enabling the profiling of HLA and KIR genotypes at a rate not seen before and raising novel questions in statistical analyses and algorithm development.

Your responsibilities:

  • You will participate in or lead research projects, analyse and interpret complex NGS data, and draft manuscripts for publication in peer-reviewed journals.
  • You will establish and apply analysis pipelines to perform large-scale de novo haplotype assembly of the MHC and KIR regions.
  • You will be involved in developing and testing data analysis infrastructure to enable HLA and KIR genotyping using single-molecule sequencing technologies.
  • You will cooperate with other departments of the company and external partners to transfer your work from an R&D setting to high-throughput routine.
  • You will prepare and deliver presentations at national and international meetings.

Must have:

  • You hold a degree in bioinformatics, computational biology, statistics, mathematics or a related field.
  • You have proven experience in bioinformatics programming (R/Bioconductor and/or Python) in a Linux/Unix environment.
  • You have expert knowledge of bioinformatics software and algorithms for next-generation sequence analysis (de novo assembly, mapping, quality assessment, variant detection, statistical inference).
  • Sound knowledge of statistics and data analysis.
  • Strong problem-solving skills and scientific creativity.
  • Excellent command of German and English, written and spoken.

Desirable:

  • Familiarity with statistical modelling (e.g., machine learning).
  • Experience with assembly graph algorithms.
  • Experience with RDBMS and knowledge of compiled languages (e.g., C++, Java, or C#).
  • Experience with the HLA genotyping.

We offer:

  • A chance to do work that directly impacts blood cancer patients all over the world.
  • A challenging and stimulating work environment with a focus on innovation.
  • An open, friendly, multicultural team that embraces a culture of trust.
  • Flexible working hours, a modern working space, and a family-friendly company culture.

DKMS is a dynamically growing organization. Our employees are highly competent and dedicated to the cause, our atmosphere is open and friendly. We are looking forward to your online application. Please be aware that we can only consider complete applications including cover letter, CV and certificates.

Apply now by Apply Now button.

Further information www.dkms.de/de.

DKMS Life Science Lab GmbH, St. Petersburger Str. 2, 01069 Dresden

dkms.de

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About DKMS Life Science Lab GmbH

Das DKMS Life Science Lab mit Sitz in Dresden ist einer der weltweit größten und fortschrittlichsten Anbieter von Genotypisierungsdiensten. Unser Hauptaugenmerk liegt auf der sequenzbasierten HLA- Typisierung mit hoher Auflösung für Stammzellspenderregister. Wir sind auch bestrebt, den Umfang unserer Dienstleistungen auf Bereiche auszudehnen, in denen unsere Kernkompetenzen den Kunden einen...
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