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Dissection of molecular pathways leading to heart diseases

We are offering one position for a scientists (Ph.D. student) at the University of Heidelberg, Department of Internal Medicine III, Cardiology.

The position in the “Department of Molecular Genetics” lead by PD Dr. Benjamin Meder, is part of the recently established “EpiGenome-Center Heidelberg”, located together with the Institute of Computational Cardiology of the University of Heidelberg. The group is also member of the German Centre for Cardiovascular Research (DZHK) (www.dzhk.de) and the Institute for Cardiomyopathies Heidelberg (ICH) (http://www.klinikum.uni-heidelberg.de/Forschung-und-Wissenschaft.137823.0.html). The well-equipped laboratory is hosting state-of-the-art research platforms such as a Next-Generation-Sequencing- and Zebrafish-Core-Facility, offering a unique scientific environment.

Background: Heart failure and cardiomyopathies are a major burden on public health in industrialized countries because they are associated with a markedly reduced life expectancy and quality of life. Molecular studies revealed several genes, proteins, and miRNAs to be involved in the pathogenesis and progression of the diseases. However, many disease mechanisms are still unknown, hindering a more individualized and effective care.

The aim of this project is to investigate the role of novel genes, epigenetic marks and miRNAs in the pathogenesis of primary and secondary heart failure and identification of suitable targets for the development of diagnostic tests.

Methods that will be used include state-of-the-art technologies for gene sequencing (next-generation sequencing), miRNA and transcriptomic profiling, and fascinating functional model systems (cell culture and zebrafish embryos) and a wide range of further molecular methods like immunohistochemistry and genetic manipulations through e.g. CRISPR/Cas9 or TALEN approaches.
The PhD student will be trained in all techniques required for the project. A team of scientists, physicians scientists, and technicians will jointly work with the students on this innovative project.

Profile of candidate‘s qualification:
Team-minded, creative. No specific previous experience is required, but a background in molecular biology and genetics are of great benefit.
We offer a highly interactive and well-equipped environment in a team with national and international partners, a broad spectrum of methods and a highly innovative topic.
The university intends to increase the number of women amongst its academic personnel and expressly encourages qualified women to apply. Preference will be given to disabled applicants with equal qualifications.

The deadline for the submission of the application is August 31st, 2015.

Further information:

Contact detail

How to apply:
Please send your application electronically or by standard mail including your CV, list of grades, and a half-page letter of motivation why you want to work on this project to University Hospital Heidelberg; AG Meder; Im Neuenheimer Feld 669; 69120 Heidelberg or via email to jan.haas@med.uni-heidelberg.de.
We will not consider incomplete or mass-mailed applications.
Send application to
Dr. Jan Haas
Analysezentrum III / Innere Medizin III
Ruprecht-Karls-Universität Heidelberg
Im Neuenheimer Feld 669
69120 Heidelberg
Tel. (office): +496221 56-38847
Tel. (lab): +496221 56-4835
email: jan.haas@med.uni-heidelberg.de


Job profile

Working hours
Contract duration
Type of job
PhD Project
Work experience
job experience is not required
Germany (Baden-Württemberg)
Working place
69120 Heidelberg
Area of expertise
Biology & Life Sciences