PhD position in immuno-biology: "Communication between neutrophilic granulocytes and other cells of the innate and adaptive immune system"

The University Medical Center of Göttingen (UMG), Dpt. of Dermatology, Venerology and Allergology, offers a PhD position in a research project analyzing the

“Communication between neutrophilic granulocytes and other cells of the innate and adaptive immune system”.

The position will be available from July 2020 or at the earliest possible date and is initially limited to 3 years (salary according to TV-L, 50%).

Cells of the innate immune system communicate with each other and with cells of the adaptive immune system to orchestrate immunologic responses. Communication between cells influence important cellular functions such as apoptosis, production of neutrophil extracellular traps (NETs) and collective cell behavior. Interestingly, the signaling molecules that neutrophilic granulocytes use to communicate with each other, are poorly characterized.

Activities and responsibilities

The goal of this project is to assess how neutrophils produce and release these signaling molecules, which receptors are engaged on the neutrophil surface and which biological effects certain signaling molecules have in neutrophil biology. Additionally, we will investigate interactions between neutrophils and other cells of the immune system such as B- and T-cells.
Prospectively, the project can be extended to encompass the interactions between neutrophils and tumor cells, particularly melanoma cells, as neutrophils appear to play a pivotal role in tumor-immunology.

We have a strong focus on microscopy (including life-cell imaging, confocal microscopy and reflection interference microscopy), physical methods such as atomic force microscopy (AFM), as well as nanotechnology-based methods to detect signaling molecules in real-time and at a very high spatial and temporal resolution. We also develop novel imaging techniques such as expansion microscopy for immune cells. Cell culture techniques, working with primary human cells and patient samples as well as murine models and standard molecular biology methods will also be part of this project.

Qualification profile

Required qualifications:
  • High motivation to solve complex biological problems
  • A strong interest in learning methods new from different disciplines
  • Interested in imaging techniques
  • The ability to think outside the box and to combine results from different fields
  • Master or Diploma in biology, physics, biophysics, biochemistry or a similar discipline
  • Willingness to co-supervise MD and master students

We offer

We offer:
  • The possibility to work on an interdisciplinary, cutting-edge project
  • Two well-equipped, modern laboratories with state-of-the-art technology
  • A highly motivated research team
  • Two highly motivated mentors
  • A position with a large amount of responsibility and a strong say in future research directions

Send application to

Please address applications (email only, one PDF including letter of motivation, certificates, CV and, facultatively, research plan/ideas) to:

PD Dr. med. Luise Erpenbeck
Dpt. of Dermatology, Venereology and Allergology (UMG)
Phone: +49-551-3910578

While applying for the job please refer to jobvector and use the following reference number: neutrophils2

About Universitätsmedizin Göttingen (UMG)

Forschungslabore der Klinik für Dermatologie, Allergologie und Venerologie der Universitätsmedizin Göttingen.
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