PhD position in Mathematical modeling of cellular heterogeneity
Mathematical modeling of heterogeneity in the SMAD signaling pathway
The TGFβ/SMAD signalling pathway plays a key role in tumorigenesis and metastasis. Together with Alexander Loewer (University of Darmstadt, Germany), we monitor the nuclear translocation of fluorescently labeled SMAD2/4 transcription factors in thousands of living MCF10A cells. Using clustering of these time course, we identified sub-populations of cells with qualitatively distinct signalling dynamics and phenotypic outcome.
In this PhD project, it is planned to further develop a mathematical modeling approach, in which we quantitatively describe the heterogeneous cell population using an ensemble of single-cell models. The model shall be employed to predict the effect of CRISPR/Cas9-mediated perturbations of the signaling pathway at the single-cell level. As a long-term goal, we plan to derive a larger network model comprising the crosstalk of pro- and anti-tumorigenic signaling pathways (e.g., MAPK and TGFβ/SMAD) based on imaging data and small-molecule-based intervention strategies. This model shall be employed to better understand deregulated growth in complex cancer cell populations.
- The possibility to work on a cutting-edge project using state-of-the-art technology in a highly motivated research team
- A stimulating, diverse and international research environment
- Advanced training opportunities
- A fully funded PhD position
- Master or Diploma
- Motivation to solve complex biological problems
- Excellent communication skills
Deadline for applications (exclusively online via web form): 10 November 2016
Please apply exclusively online via our web forms:
While applying for the job please refer to jobvector and use the following reference number: JV-C11-SL1
About Institute of Molecular Biology gGmbH
Our International PhD Programme on the “Gene Regulation, Epigenetics and DNA Damage Response” gives talented and enthusiastic students the opportunity to undertake PhD research at the cutting edge of modern biology. Our groups cover a broad range of expertise and include leading biochemists, geneticists, cell and developmental biologists who study the molecular mechanisms of...More about Institute of Molecular Biology gGmbH