PhD project: Decoding the functions of ubiquitin in the cellular response to DNA damage

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In the field of  “Ubiquitin signaling and mass spectrometry-based proteomics” the research group of Dr. Petra Beli offers the following PhD project: Decoding the functions of ubiquitin in the cellular response to DNA damage

Description:

Dynamic modification of proteins with ubiquitin after DNA damage has been shown to play a central role in all DNA repair pathways. In this regard, protein ubiquitination has most frequently been associated with the recruitment of DNA repair factors – many containing ubiquitin-binding domains –to DNA lesions and lesion flanking chromatin. The aim of this project is to identify the protein substrates and characterize the functions of selected nuclear ubiquitin ligases that are important for cellular survival after DNA damage. To this end, the prospective PhD student will employ a range of methods including mass spectrometry-based proteomics as well as advanced cell biological and biochemical methods such as flow cytometry, confocal microscopy, next generation sequencing and genome editing techniques.

We offer
• The possibility to work on a cutting-edge project using state-of-the-art technology in a highly motivated research team
• A stimulating, diverse and international research environment
• Advanced training opportunities
• A competitive stipend

Required qualifications
• Master or Diploma
• Motivation to solve complex biological problems
• Excellent communication skills

Starting date: 1 April 2016 or later
Duration of stipend: 3 years, with the possibility of extension
Deadline for registration (exclusively online via web form):  8 November 2015

  

Contact detail


How to apply:
Please apply exclusively via our online form at:
https://www.imb-mainz.de/students-postdocs/international-phd-programme/apply-to-ipp/registration-and-application/
Send application to
For further questions and contact information please check our website:
http://www.imb.de/PhD

Job profile


Working hours
Full-Time
Contract duration
Permanent
Type of job
PhD Project
Work experience
job experience is not required
Region
Germany (Rheinland-Pfalz)
Working place
55128 Mainz
Area of expertise
Biology & Life Sciences

About Institute of Molecular Biology gGmbH

Our International PhD Programme on the “Gene Regulation, Epigenetics and DNA Damage Response” gives talented and enthusiastic students the opportunity to undertake PhD research at the cutting edge of modern biology. Our groups cover a broad range of expertise and include leading biochemists, geneticists, cell and developmental biologists who study the molecular mechanisms of...

More about Institute of Molecular Biology gGmbH

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