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PhD project: Presence, function and evolutionary aspects of the PIWI/piRNA system in post-mitotic somatic tissue in humans and primate models

In the field of  “Somatic function of the PIWI/piRNA system in human and non-human primate evolution” the research group of Prof. Hans Zischler and Dr. David Rosenkranz offers the following PhD project: Studying novel DNA modification and DNA editing by mass spectrometry

Description:

Modified DNA bases play an important epigenetic role in the regulation of gene expression in development and disease. In mammals there are four different cytidine modifications in genomic DNA known to have an epigenetic function, most prominently 5-hydroxymethylcotosine. There are many more known DNA modifications, whose function remain unknown and await characterisation, including of the cellular enzymes that affect these modifications, which will be the aim of the project. Our lab has a broad expertise not only in molecular cell biology and bioinformatics, but in bioanalytical chemistry, where we are using LC/MS/MS detection for modified nucleobases. Beyond mass spectrometry analysis, we will knockout candidate genes in mouse embryonic stem cells (mESCs) by the CRISPR/Cas9 genome editing technique and analyze the physiological relevance of these genes in pluripotency and during mESC in vitro differentiation by e.g. RNA sequencing. Given the biological importance of the new DNA modification, the project promises to be ground breaking, opening unexplored fields in epigenetics. This PhD project will be particularly suited for students with interest in biochemistry and/or bioorganic analytical methods, particularly mass spectrometry.  

We offer
• The possibility to work on a cutting-edge project using state-of-the-art technology in a highly motivated research team
• A stimulating, diverse and international research environment
• Advanced training opportunities
• A competitive stipend

Required qualifications
• Master or Diploma
• Motivation to solve complex biological problems
• Excellent communication skills

Starting date: 1 April 2016 or later
Duration of stipend: 3 years, with the possibility of extension
Deadline for registration (exclusively online via web form):  8 November 2015

For further questions and contact information please check our website:
http://www.imb.de/PhD

Please apply exclusively via our online form at:
https://www.imb-mainz.de/students-postdocs/international-phd-programme/apply-to-ipp/registration-and-application/

 
How to apply:
Please apply exclusively via our online form at:
https://www.imb-mainz.de/students-postdocs/international-phd-programme/apply-to-ipp/registration-and-application/
 
Send application to
For further questions and contact information please check our website:
http://www.imb.de/PhD
While applying for the job please refer to jobvector and use the following reference number: JV-C9-HZ

About Institute of Molecular Biology gGmbH

Our International PhD Programme on the “Gene Regulation, Epigenetics and DNA Damage Response” gives talented and enthusiastic students the opportunity to undertake PhD research at the cutting edge of modern biology. Our groups cover a broad range of expertise and include leading biochemists, geneticists, cell and developmental biologists who study the molecular mechanisms of...

More about Institute of Molecular Biology gGmbH

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