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PhD project: The role of demethylation genes in Xenopus embryonic development

In the field of  “DNA demethylation” the research group of Prof. Christof Niehrs offers the following PhD project: The role of demethylation genes in Xenopus embryonic development 

Description:

To unravel the biological role played by genes in active DNA demethylation we are using the Xenopus frog system. Xenopus embryos are a powerful model system to study embryonic patterning and differentiation. Tools such as mRNA overexpression and antisense Morpholino injection yield facile access to functional analysis of gene function. These studies have raised interesting questions: What are the demethylation target genes in Xenopus? What is the role of demethylating genes such as Gadd45 or Neil DNA glycosylases? Does demethylation in Xenopus involve oxidised cytosine intermediates? We will combine genome-wide expression and methylation analysis. Global expression profiling by microarrays and/or RNA-sequencing in combination with global methylation profiling using MeDIP and ChIP-Seq will lead to the identification of direct demethylation target genes in this differentiation process.   

We offer
• The possibility to work on a cutting-edge project using state-of-the-art technology in a highly motivated research team
• A stimulating, diverse and international research environment
• Advanced training opportunities
• A competitive stipend

Required qualifications
• Master or Diploma
• Motivation to solve complex biological problems
• Excellent communication skills

Starting date: 1 April 2016 or later
Duration of stipend: 3 years, with the possibility of extension
Deadline for registration (exclusively online via web form):  8 November 2015

For further questions and contact information please check our website:
http://www.imb.de/PhD

Please apply exclusively via our online form at:
https://www.imb-mainz.de/students-postdocs/international-phd-programme/apply-to-ipp/registration-and-application/
 

How to apply:
Please apply exclusively via our online form at:
https://www.imb-mainz.de/students-postdocs/international-phd-programme/apply-to-ipp/registration-and-application/
Send application to
For further questions and contact information please check our website:
http://www.imb.de/PhD
While applying for the job please refer to jobvector and use the following reference number: JV-C9-CN3

About Institute of Molecular Biology gGmbH

Our International PhD Programme on the “Gene Regulation, Epigenetics and DNA Damage Response” gives talented and enthusiastic students the opportunity to undertake PhD research at the cutting edge of modern biology. Our groups cover a broad range of expertise and include leading biochemists, geneticists, cell and developmental biologists who study the molecular mechanisms of...

More about Institute of Molecular Biology gGmbH

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