Postdoctoral Position in Immunology and Epithelial Transport Physiology
The kidney is a primary target for crystals because of its role in filtering and eliminating various substances via the urine. As poorly soluble molecules and waste salts are being concentrated in the course of urine formation, crystals can build and deposit within the renal tubules and interstitium resulting in kidney failure. The composition of crystals varies based on whether they are introduced as drugs (e.g. methotrexate, sufadiazine or indinavir) or endogenous to the body (e.g. light chain crystalline nephropathy or uric acid nephropathy). Our laboratory primarily focuses on oxalate, the most common component of urinary crystals in humans. Our highly interdisciplinary investigations stretch from transport physiology studies, biophysics to animal models as well as observational and intervention studies in patients.
The research will focus on the mechanism of how crystals activate innate immune cells (macrophages and dendritic cells) in vitro and in vivo. We have established a mouse model of crystal-induced organ failure that the candidate will be examining. The project aims to define the role of the inflammasome in release of cytokines and progression of systemic diseases. In addition, the candidate will be able to examine the hypothesis in a translational approach by investigating an established patient cohort (GCKD study).
The group leader is shared grant holder and coordinator of the DAAD thematic network TRENAL (www.trenal.net). This research network has been established between Erlangen University, Yale University and University College London (UCL). Hence, the qualified postdoctoral candidate will have the opportunity for fully funded research stays and conferences at Yale University or UCL based on performance.
While applying for the job please refer to jobvector and use the following reference number: KN 2016-2
About Universität Erlangen
Die Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) ist mit fast 38.000 Studenten die zweitgrößte unter den Universitäten Bayerns und wurde 1742/43 gegründet. Ihren Sitz hat sie in Erlangen, ihr zweiter großer Standort ist in Nürnberg.More about Universität Erlangen