Regulation of intracellular transport in neurons

The Institute for Molecular Cell Biology at the University of Münster is looking for a
PhD student (TVL-13 65%, 3 years starting August 2019 or later) to investigate the

Regulation of intracellular transport in neurons

The polarized transport of organelles is essential to establish and maintain the complex architecture of the mammalian neocortex. Defects in intracellular transport disrupt cortical development and lead to neurodevelopmental disorders and neurodegenerative diseases. We are investigating the molecular and cellular mechanisms of intracellular transport during neuronal development in mice. In particular, we are interested in understanding how the transport of mitochondria and vesicles is regulated and linked to neuronal differentiation. The project involves the functional analysis of factors regulating intracellular transport and mitochondrial dynamics. It includes the development of optogenetic tools and genetically encoded sensors to analyze intracellular transport and membrane dynamics by live cell imaging.

For an overview of ongoing projects visit:
https://www.uni-muenster.de/Biologie.IMZ/pueschel/
https://www.uni-muenster.de/CiM-IMPRS/research/projects/pueschel.html
http://sfb1348.uni-muenster.de/projects/b/project-b03

Activities and responsibilities

We are looking for highly motivated candidates with an interest in understanding fundamental questions of neurobiology at the molecular and cellular level. The project will employ a combination of molecular, cell biological, and genetic techniques in combination with life cell imaging to study differentiation in cultured neurons, organotypic slice cultures and knockout mice.

Qualification profile

Experience in life cell imaging or the culture of neurons is an advantage but not required.

Benefits

The position is available initially for 3 years starting August 2019 or later. 
We offer an international environment with English as the language spoken in the laboratory. Successful candidates are expected to join the CiM-IMPRS graduate program (https://www.uni-muenster.de/CiM-IMPRS/). The University of Münster is an equal opportunity employer.

Send application to

Applications (including CV, a brief summary of the Master's project and Transcript of Records) can be sent by
e-mail until June 14 to apuschel@uni-muenster.de

Prof. Andreas Püschel
Institute for Molecular Cell Biology
University of Münster
Schlossplatz 5
48149 Münster
Germany

Average salary for comparable positions is about € 32.748,00 gross per year. Depending on experience and qualifications, as well as other factors, this estimate may deviate to varying degrees from salaries actually to be expected.
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