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Doctoral Researcher Position: Endoplasmatic reticulum turnover and outcome of sepsis

The Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute – in cooperation with the Friedrich Schiller University, the University Hospital Jena and the Max Planck Institute for Chemical Ecology are offering an international graduate training programme. The
 
International Leibniz Research School (ILRS Jena)
 
gives doctoral researchers the possibility to prepare for their PhD exam in an ambitious program providing excellent research conditions. We invite applications for a
 
Doctoral Researcher Position (Ref.No. ILRS_01/2016)
Endoplasmatic reticulum turnover and outcome of sepsis
 
Autophagy is an evolutionarily conserved strategy to respond to organelle damage. Stress events associated with infection, such as “pathogen-associated molecular pattern” receptor signaling, hypoxia and redox changes, as well as protein unfolding are well known triggers to induce autophagy limiting the development of tissue injury and subsequent organ dysfunction. Damaged organelles, including ER are captured by the isolation membrane. The resulting autophagosome then fuses with lysosomes, initiating degradation and recycling. Consequently, autophagy and its manipulation by pathogens may modulate host resistance primarily via tissue damage control, and disease tolerance in the context of infection. The few experimental data available so far suggest beneficial effect via a mechanism involving components of the unfolded protein as well as autophagy damage response, e.g. the autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) and the autophagy-related protein 7 (Atg7) primarily implying a role in mitophagy. Thus, mitophagy (and autophagy in general) might provide tissue damage control in parenchymal tissues conferring disease tolerance to sepsis, i.e. infection associated with an inappropriate host response characterized by organ dysfunction.
Members of the reticulon protein family, i.e. FAM134, that act as ER-resident receptors binding autophagy modifiers such as LC3B have recently been shown to facilitate ‘ER-phagy’. FAM134B facilitated ER-phagy reflects a central housekeeping mechanism and its lack leads to sensory neuropathy. The FAM134 family of proteins consists of 3 isoforms with different tissue-specific expression patterns but their role under inflammatory stress conditions remains unknown. We hypothesize that these proteins differentially modulate tissue-specific stress responses upon life-threatening infections ultimately protecting against development of, or propagating resolution from multi-organ dysfunction associated with sepsis.
 
We expect:
  • a Master’s degree (or equivalent allowing you to pursue a PhD degree) in Natural or Life Sciences. Research at ILRS is centred around “Microbial and Biomolecular Interactions”. Candidates about to earn their degree are welcome to apply.
  • high motivation and interest to join one of the research areas of ILRS
  • creativity and interest in shaping your own thesis project
  • an integrative and cooperative personality with enthusiasm for actively participating in our lively community
  • very good communication skills in English
We offer:
  • a top-level research environment
  • efficient supervision by a team of advisors
  • a comprehensive mentoring programme
  • courses in state-of-the-art technologies and soft skills
  • strong communication and interaction between the involved institutions
  • Jena – City of Science: innovative business activities, successful scientific centres and a vibrant cultural scene around the famous Friedrich Schiller University
The three-year Doctoral Researcher position is available starting from July 2016. Salary will be paid according to TV-L (salary agreement for public service employees). HKI is an equal opportunity employer.

Further information:
Prof. Dr. Michael Bauer, PI,  michael.bauer@med.uni-jena.de
Dr. Christine Vogler, ILRS Coordinator, ilrs@leibniz-hki.de

The application process is handled exclusively online. Please acquaint yourself with the scientific projects offered on our website and thoroughly follow the instructions for the online application process:
www.ilrs.de/vacant-projects.html

Deadline for application: Apr 14, 2016.
Successful applicants will be invited to attend a recruitment meeting in Jena (envisaged date: Jun 09-10, 2016).

Contact detail


How to apply:
The application process is handled exclusively online. Please acquaint yourself with the scientific projects offered on our website and thoroughly follow the instructions for the online application process:
www.ilrs.de/vacant-projects.html

Online Application at https://www.uni-jena.de/jsmc_online_application
 
Send application to
Dr. Christine Vogler, ILRS Coordinator, ilrs@leibniz-hki.de
 

Job profile


Working hours
Full-Time
Contract duration
Temporary
Type of job
PhD Project
Work experience
job experience is not required
Region
Germany (Thüringen)
Working place
07745 Jena
Area of expertise
Biology & Life Sciences, Human medicine, Biotechnology