Doctoral Researcher Position: The impact of the interaction of the receptors of the Dectin-1 gene cluster in fungal and bacterial infections
International Leibniz Research School (ILRS Jena)
The impact of the interaction of the receptors of the Dectin-1 gene cluster in fungal and bacterial infections
We hypothesized that the interaction of the ITIM or ITAM bearing receptors of the Dectin-1 gene cluster are fine-tuning pathogen-dependent immune responses in particular of Dectin-1 and LOX-1. In addition LOX-1 one might be an important and so far under recognized receptor for the detection of bacterial and maybe also for fungal pathogens.
In the proposed study the following aims will be addressed:
(i) Analysis of the quantitative expression profiles of the receptors of the dectin-1 cluster on human innate immune cells (granulocytes, monocytes, macrophages, NK cells) and pulmonary epithelial cells
(ii) Generation of cells that differentially are expressing receptors of the Dectin-1 cluster by using the CRISPR/Cas-System (Clustered Regularly Interspaced Short Palindromic Repeats) and subsequent functional analysis of the receptor interactions
- a Master’s degree (or equivalent allowing you to pursue a PhD degree) in Natural or Life Sciences. Research at ILRS is centred around “Microbial and Biomolecular Interactions”. Candidates about to earn their degree are welcome to apply.
- high motivation and interest to join one of the research areas of ILRS
- creativity and interest in shaping your own thesis project
- an integrative and cooperative personality with enthusiasm for actively participating in our lively community
- very good communication skills in English
- very good skills in transfection of cells are desirable
- a top-level research environment
- efficient supervision by a team of advisors
- a comprehensive mentoring programme
- courses in state-of-the-art technologies and soft skills
- strong communication and interaction between the involved institutions
- Jena – City of Science: innovative business activities, successful scientific centres and a vibrant cultural scene around the famous Friedrich Schiller University
The three-year Doctoral Researcher position is available starting from July 2016. Salary will be paid according to TV-L (salary agreement for public service employees). HKI is an equal opportunity employer.
Prof. Dr. Hortense Slevogt, PI, firstname.lastname@example.org
Dr. Christine Vogler, ILRS Coordinator, email@example.com
The application process is handled exclusively online. Please acquaint yourself with the scientific projects offered on our website and thoroughly follow the instructions for the online application process:
Deadline for application: Apr 14, 2016.
Successful applicants will be invited to attend a recruitment meeting in Jena (envisaged date: Jun 09-10, 2016).
While applying for the job please refer to jobvector and use the following reference number: ILRS_03/2016
Online Application at: https://www.uni-jena.de/jsmc_online_application/
About International Leibniz Research School for Microbial and Biomolecular Interactions
The Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute - in cooperation with the Friedrich-Schiller-University and the Max Planck Institute for Chemical Ecology are offering an international graduate program. The International Leibniz Research School (ILRS Jena) gives doctoral researchers the possibility to prepare for their PhD exam in an...More about International Leibniz Research School for Microbial and Biomolecular Interactions